补脾胃泻阴火升阳汤联合美沙拉嗪治疗溃疡性结肠炎患者临床疗效观察

发布时间：2019-04-23 21:01

【摘要】：目的:观察补脾胃泻阴火升阳汤联合美沙拉嗪治疗溃疡性结肠炎的临床疗效及对炎症细胞因子的影响。方法:选择符合纳入标准的溃疡性结肠炎患者195例,采用简单数字的随机方法分为对照1组,对照2组和治疗组,每组65例。对照1组给予美沙拉嗪肠溶片口服,1 g/次,3次/d(tid),对照2组患者在口服美沙拉嗪肠溶片的基础上给予陈李济补脾益肠丸口服,6 g/次,tid。治疗组患者在口服美沙拉嗪肠溶片的基础上给予补脾胃泻阴火升阳汤口服,每次100 mL,tid。观察3组患者治疗前后症状、大肠黏膜积分变化和细胞因子高敏C反应蛋白(high sensitivity C-reaction protein,hs-CRP),白细胞介素-6(interleukin-6,IL-6),肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平变化,统计临床疗效。结果:治疗组治疗后在证候积分(腹痛、腹泻、脓血便),大肠黏膜积分、细胞因子(hs-CRP,IL-6,TNF-α)水平较对照1组,对照2组均明显降低(P0.05);治疗组,对照1组,对照2组临床疗效总有效率分别为93.85%,78.46%,81.54%,治疗组临床疗效优于对照1组,对照2组(P0.05)。结论:补脾胃泻阴火升阳汤联合美沙拉嗪能够有效地缓解溃疡性结肠炎患者临床症状及大肠黏膜病变,改善细胞因子水平,值得进一步推广及应用。
[Abstract]:Aim: to observe the clinical efficacy and inflammatory cytokines in the treatment of ulcerative colitis with the combination of spleen-tonifying stomach purging Yin-Huo-Sheng Yang decoction and Mesalazine. Methods: 195 patients with ulcerative colitis were randomly divided into control group (n = 65), control group 2 (n = 65) and treatment group (n = 65). Control group 1 was given mesalazine enteric solution tablets, 1 g / time, 3 times / d (tid), control group 2 patients were given Chen Li Ji Bu Pi Yi Chang Pill on the basis of oral mesalazine enteric solution tablets, 6 g / time, tid. The patients in the treatment group were treated with tonifying spleen, stomach, purging yin, fire and rising yang decoction on the basis of oral mesalazine enteric-coated tablets for 100 mL,tid. each time. Before and after treatment, symptoms, changes of intestinal mucosal integral, cytokine Gao Min C-reactive protein (high sensitivity C-reaction protein,hs-CRP and interleukin-6 (interleukin-6,IL-6) were observed. The level of tumor necrosis factor-伪 (tumor necrosis factor- 伪 (TNF- 伪) was changed, and the clinical curative effect was counted. Results: after treatment, the scores of syndrome (abdominal pain, diarrhea, purulent blood stool), intestinal mucosal integral and cytokines (hs-CRP,IL-6,TNF- 伪) in the treatment group were significantly lower than those in the control group 1 and control group 2 (P0.05). The total effective rates of the treatment group, control group 1 and control group 2 were 93.85%, 78.46% and 81.54%, respectively. The clinical efficacy of the treatment group was better than that of the control group 1 and control 2 (P0.05). Conclusion: spleen-tonifying stomach purging Yin-fire-rising Yang decoction combined with methalazine can effectively relieve the clinical symptoms and pathological changes of large intestinal mucosa in patients with ulcerative colitis, and improve the level of cytokines, which is worthy of further popularization and application.
【作者单位】：唐山市工人医院;唐山市中医医院;华北理工大学中医学院;
【基金】：河北省中医药管理局2015年度中医药类科研计划课题项目(2015236)
【分类号】：R574.62

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