适量饮酒与脂肪性肝病或非酒精性脂肪性肝病发病风险的Meta分析

发布时间：2019-04-27 20:34

【摘要】：目的系统评价适量饮酒与脂肪性肝病(FLD)或非酒精性脂肪性肝病(NAFLD)发病风险的关系。方法检索Pub Med、EMbase、Wed of Science、The Cochrane Library、中国知网(CNKI)、万方数据库、维普数据库(VIP)中关于适量饮酒与FLD或NAFLD发病风险关系的研究。检索时限从建库至2015年11月。采用Stata12.0统计软件进行Meta分析。结果共纳入16个研究,包括13个横断面研究,2个横断面加纵向研究,1个队列研究,研究对象共计76 967例。Meta分析结果显示:1微量及少量饮酒可使FLD或NAFLD的发病风险分别降低17%及27%,而中量饮酒组边缘性地与FLD或NAFLD的发病风险降低相关。2不同性别亚组结果显示:女性微量及少量饮酒可使FLD或NAFLD发病风险分别降低29%及33%,但女性中量饮酒与对照组相比无统计学差异;男性少量饮酒可使FLD或NAFLD发病风险降低23%,但男性微量及中量饮酒与对照组相比无统计学差异,亚洲男性少量及中量饮酒可使FLD或NAFLD的发病风险分别降低29.7%及30.3%。结论适量饮酒可能不增加FLD或NAFLD的发病风险;相反,女性微量及少量饮酒可显著降低FLD或NAFLD的发病风险,而男性,尤其是亚洲男性少量及中量饮酒亦可显著降低FLD或NAFLD的发病风险。
[Abstract]:Objective to evaluate the relationship between moderate alcohol consumption and the risk of (FLD) or (NAFLD) in patients with fatty liver disease (FLD) or non-alcoholic fatty liver disease (NALD). Methods the relationship between moderate alcohol consumption and the risk of FLD or NAFLD was studied in (CNKI), Wanfang database of Pub Med,EMbase,Wed of Science,The Cochrane Library, China knowledge Network and (VIP) database of Vip database. Search time limit from the construction of the library to November 2015. Meta analysis was carried out with Stata12.0 statistical software. Results A total of 16 studies were included, including 13 cross-sectional studies, 2 cross-sectional plus longitudinal studies, and 1 cohort study. A total of 76 967 subjects were enrolled in the study. Meta-analysis showed that: (1) the risk of FLD or NAFLD was reduced by 17% and 27%, respectively, with a small amount of alcohol consumption and a small amount of alcohol consumption. The risk of FLD or NAFLD in moderate dose drinking group was significantly lower than that in moderate dose alcohol group. 2 the results of sex-specific subgroup showed that the risk of FLD or NAFLD was reduced by 29% and 33% respectively in women with moderate alcohol consumption and a small amount of alcohol consumption, and the risk of FLD or NAFLD decreased by 29% and 33% respectively. However, there was no significant difference in moderate alcohol consumption between female and control group. A small amount of alcohol consumption in men reduced the risk of FLD or NAFLD by 23%, but there was no significant difference between men and the control group in drinking alcohol in small and moderate doses. Low and moderate alcohol consumption in Asian men reduced the risk of FLD or NAFLD by 29.7% and 30.3%, respectively. Conclusion moderate drinking may not increase the risk of FLD or NAFLD. On the contrary, small and small amounts of alcohol consumption in women significantly reduced the risk of FLD or NAFLD, while a small and moderate dose of alcohol consumption in men, especially in Asian men, significantly reduced the risk of FLD or NAFLD.
【作者单位】：暨南大学附属第一医院消化内科;
【分类号】：R575

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