幽门螺杆菌在胃黏膜中不同形态感染的病理研究

发布时间：2019-05-08 04:59

【摘要】：目的探讨胃黏膜中不同形态幽门螺杆菌感染引起的胃部疾病的病理特点,降低胃部幽门螺杆菌感染率。方法选取2011年4月-2014年3月行胃黏膜活检的患者219例,采用不同的染色方法观察幽门螺杆菌的形态,并观察胃黏膜的形影病理学改变;采用SPSS13.0软件进行分析。结果螺旋状伴球形幽门螺杆菌男性患者所占比例明显高于单纯球形幽门螺杆菌患者,两种形态幽门螺杆菌之间差异有统计学意义(P0.05);两种形态幽门螺杆菌患者黏膜类型、炎症类型以及是否伴有异型增生差异无统计学意义;螺旋状伴球形幽门螺杆菌有炎症活动、重度炎症、有滤泡形成者分别占79.35%、55.43%和50.00%;单纯球形幽门螺杆菌患者分别占43.75%、25.00%和25.00%,螺旋状伴球形幽门螺杆菌明显高于单纯球形螺杆菌,两种形态比较差异有统计学意义(P0.05)。结论球形幽门螺杆菌与螺旋状幽门螺杆菌均对胃黏膜具有致病性,且螺旋状幽门螺杆菌的致病性更强,而男性存在该形态螺杆菌相对较多,临床应予以注意。
[Abstract]:Objective to investigate the pathological characteristics of gastric diseases caused by different forms of Helicobacter pylori infection in gastric mucosa and to reduce the infection rate of Helicobacter pylori in gastric mucosa. Methods from April 2011 to March 2014, different staining methods were used to observe the morphology of Helicobacter pylori and the morphological and pathological changes of gastric mucosa, and the results were analyzed by SPSS13.0 software. Results the proportion of male patients with spiral helicobacter pylori was significantly higher than that of patients with pure spherical Helicobacter pylori, and there was a significant difference between the two forms of Helicobacter pylori (P0.05). There was no significant difference in mucosal type, inflammatory type and dysplasia between the two forms of Helicobacter pylori. Helicobacter pylori had inflammatory activity, severe inflammation and follicular formation accounted for 79.35%, 55.43% and 50.00% respectively. Patients with simple spherical Helicobacter pylori accounted for 43.75%, 25.00% and 25.0%, respectively. Spiral Helicobacter pylori with spherical Helicobacter pylori was significantly higher than pure spherical Helicobacter pylori, and there was significant difference between the two groups (P0.05). Conclusion both spherical Helicobacter pylori and helix Helicobacter pylori have pathogenicity to gastric mucosa, and the pathogenicity of spiral Helicobacter pylori is stronger than that of male, so it is necessary to pay attention to it in clinical practice. [WT5 "HZ] [WT5" HZ] conclusion [WT5 "BZ]
【作者单位】：达州职业技术学院病理学教研室;达州职业技术学院病原微生物及免疫学教研室;四川省达县人民医院内二科;
【基金】：四川省卫生厅基金资助项目(CW-2011B-092)
【分类号】：R573

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