抗凝血酶原Ⅲ及CA125水平变化与肝硬化患者不同Child-Pugh分级的关系

发布时间：2019-06-05 04:24

【摘要】：目的研究抗凝血酶原Ⅲ(AT-Ⅲ)及CA125的水平变化与肝硬化患者不同Child-Pugh分级的相关性。方法收集肝硬化患者50例作为肝硬化组,按照Child-Pugh分级分为A、B、C 3级,并以同一时期的健康体检者30例作为对照组进行对比,检测两组AT-Ⅲ与CA125水平。结果肝硬化组AT-Ⅲ为(50.04±20.98)%,对照组AT-Ⅲ为(102.85±10.46)%,两组差异有统计学意义(t=-12.842,P0.001);AT-Ⅲ在A级、B级及C级之间相互比较,差异有统计学意义(P0.05)。肝硬化组CA125为(127.34±196.24)U/m L,对照组CA125为(12.84±6.55)U/m L,两组差异有统计学意义(t=5.164,P0.001);而A级与B级、C级比较,差异有统计学意义(P0.05),B级与C级间差异无统计学意义(P0.05)。血浆AT-Ⅲ与Child-Pugh分级呈负相关(r=-0.583,P0.05),血清CA125与Child-Pugh分级呈正相关(r=0.427,P0.05)。结论肝硬化患者血浆AT-Ⅲ与血清CA125的水平变化可反映其肝功能损害程度。
[Abstract]:Objective to study the relationship between the levels of antithrombin III (AT- III) and CA125 and different Child-Pugh grades in patients with liver cirrhosis. Methods 50 patients with liver cirrhosis were divided into A, B and C 3 according to Child-Pugh grade, and 30 healthy subjects in the same period were used as control group. The levels of AT- III and CA125 in the two groups were measured. Results AT- III was (50.004 卤20.98)% in cirrhotic group and (102.85 卤10.46)% in control group. There was significant difference between the two groups (t 鈮，

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