声脉冲辐射力成像评价恩替卡韦、复方鳖甲软肝片联合治疗肝纤维化的疗效研究

发布时间：2019-06-06 04:09

【摘要】：目的:使用声脉冲辐射力成像技术(ARFI),评价在恩替卡韦分散片抗病毒的基础上联合复方鳖甲软肝片治疗慢性乙型肝炎肝纤维化的疗效。方法:对96例慢性乙型肝炎患者经恩替卡韦分散片联合复方鳖甲软肝片治疗前后行声脉冲辐射力成像检查,记录所检测到的VTQ值,并同时检测肝功能、肝纤维化指标等,观察时间节点为24和48周,分析VTQ值、肝功能、肝纤维化指标的变化。计量资料用(xs恕纒)表示,采用t检验,P0.05为差异有统计学意义。结果 96例患者在治疗24周及48周,患者的VTQ值、常规检查的肝功能指标(ALT、AST)和肝纤维化指标(HA、LN、CIV和PCⅢ)均较治疗前明显降低(P0.05);且治疗48周后的VTQ值、肝纤维化指标也分别显著低于治疗24周后的值(P0.05),然而,48周后肝功能指标相对24周的值没有统计学意义(P0.05)。结论与传统肝纤维化指标相比,声脉冲辐射力成像是一种简便可靠的临床检查肝纤维化及评价疗效的技术手段。同时,该临床研究也表明:恩替卡韦分散片联合复方鳖甲软肝片是治疗慢性乙型肝炎肝纤维化的有效组合。
[Abstract]:Objective: to evaluate the efficacy of compound Biejia Ruangan tablet in the treatment of chronic hepatitis B liver fibrosis on the basis of antiviral effect of entecavir dispersible tablets by acoustic pulse radiation force imaging (ARFI),). Methods: 96 patients with chronic hepatitis B were examined by acoustic pulse radiation force imaging before and after treatment with entecavir dispersible tablets combined with compound Biejia Ruangan tablet. The VTQ values were recorded, and the liver function and liver fibrosis indexes were detected at the same time. The changes of VTQ, liver function and hepatic fibrosis were analyzed at 24 and 48 weeks after observation. The measurement data were expressed by (xs forgiveness). T test was used to show that the difference was statistically significant (P 0.05). Results at 24 and 48 weeks of treatment, the VTQ value, liver function index (ALT,AST) and liver fibrosis index (HA,LN,CIV and PC III) of 96 patients were significantly lower than those before treatment (P 0.05). The VTQ value and hepatic fibrosis index after 48 weeks of treatment were significantly lower than those after 24 weeks of treatment (P 0.05). However, there was no significant difference in liver function index compared with 24 weeks after 48 weeks treatment (P 0.05). Conclusion compared with the traditional indexes of liver fibrosis, acoustic pulse radiation force imaging is a simple and reliable technical method for clinical examination of liver fibrosis and evaluation of curative effect. At the same time, the clinical study also showed that entecavir dispersible tablets combined with compound Biejia Ruangan tablet is an effective combination in the treatment of chronic hepatitis B liver fibrosis.
【作者单位】：宁波市第二医院;
【基金】：卫生部部属(管)医疗机构临床学科重点项目建设专项资金项目(CFHPC20132074)
【分类号】：R575.2

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