市售氯己定类消毒剂复配现状及其含量调查

发布时间：2018-01-15 10:20

本文关键词：市售氯己定类消毒剂复配现状及其含量调查　出处：《中国消毒学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的了解氯己定类消毒产品的使用情况。方法调查141件氯己定类消毒产品配方成分、含量标注等信息,采用高效液相色谱法对17件消毒监督抽检氯己定类产品进行含量检测。结果调研产品中的氯己定消毒有效成分有醋酸氯己定、葡萄糖酸氯己定和氯己定,醋酸氯己定类产品居多;多数产品均以复配为主,复配主要成分为乙醇和碘;适用于不同消毒对象的产品有不同的含量要求,皮肤及手消毒剂有效成分含量以0.5%居多;消毒抽检样品复配及含量等情况与调研结果一致,有1件产品不合格。结论氯己定类消毒产品的调研结果基本能反映氯己定的使用情况,氯己定产品复配及含量情况复杂,应加强对消毒产品的监督及安全性评价。
[Abstract]:Objective to investigate the usage of chlorhexidine disinfection products. Methods 141 chlorhexidine disinfection products were investigated. High performance liquid chromatography (HPLC) was used to determine the content of chlorhexidine acetate, chlorhexidine gluconate and chlorhexidine gluconate. Chlorhexidine acetate products are the majority; Most of the products were composed mainly of ethanol and iodine. The products suitable for different disinfection objects have different content requirements, and the content of active components of skin and hand disinfectants is more than 0.5%; The combination and content of disinfection samples were consistent with the investigation results, and one product was not qualified. Conclusion the investigation results of chlorhexidine disinfection products can basically reflect the use of chlorhexidine. The compound and content of chlorhexidine products are complex, so the supervision and safety evaluation of disinfection products should be strengthened.
【作者单位】：中国疾病预防控制中心环境与健康相关产品安全所;
【分类号】：R187
【正文快照】： 氯己定(俗称洗必泰),属双胍类化合物,具有较强的广谱抑菌、杀菌作用且毒性小,性质稳定[1-3],作为消毒有效成分广泛应用于消毒产品中,一般用于手、皮肤和黏膜的消毒。氯己定难溶于水,实际消毒产品中多采用溶解度好的胍盐,如醋酸氯己定、盐酸氯己定和葡萄糖酸氯己定[4]。目前氯

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