基于毒理学关注阈值方法的邻苯二甲酸二甲酯和邻苯二甲酸二乙酯的风险评估

发布时间：2018-01-17 02:33

本文关键词：基于毒理学关注阈值方法的邻苯二甲酸二甲酯和邻苯二甲酸二乙酯的风险评估　出处：《中国食品卫生杂志》2016年02期 　论文类型：期刊论文

【摘要】：目的运用毒理学关注阈值(TTC)方法对邻苯二甲酸二甲酯(DMP)和邻苯二甲酸二乙酯(DEP)两种邻苯二甲酸酯类物质进行风险评估。方法利用TTC决策树方法和Toxtree软件对DMP和DEP进行Cramer结构分类;利用2002年中国居民营养与健康状况调查数据和24类主要食物中DMP和DEP的含量数据,估计中国不同年龄组人群DMP和DEP的膳食暴露量,并按照TTC决策树方法对其进行风险评估。结果 DMP和DEP属于Cramer I类结构,其对应的TTC阈值为30μg/kg BW。中国居民的DMP和DEP最大暴露量分别为2.43和1.72μg/kg BW,占TTC阈值的8.10%和5.72%;划分成8个性别年龄组后的最大暴露量分别为2.01和1.44μg/kg BW,占TTC阈值的6.71%和4.79%。结论中国居民膳食DMP和DEP的健康风险较低,不需要引起健康关注。
[Abstract]:Objective to apply Toxicology focus threshold (TTC) method to the determination of dimethyl phthalate (DMPP) and diethyl phthalate (DEP). Methods TTC decision tree method and Toxtree software were used to classify the structure of DMP and DEP. The dietary exposure to DMP and DEP in different age groups in China was estimated by using the data of the 2002 survey of nutrition and health status of Chinese residents and the contents of DMP and DEP in 24 kinds of main foods. The risk was evaluated according to TTC decision tree method. Results DMP and DEP belong to Cramer I structure. The corresponding TTC threshold was 30 渭 g / kg BW.The maximum exposure of DMP and DEP to Chinese residents was 2.43 and 1.72 渭 g / kg BW, respectively. The TTC threshold was 8.10% and 5.72; The maximum exposure was 2.01 渭 g / kg BW and 1.44 渭 g / kg BW, respectively. Conclusion the health risks of dietary DMP and DEP in Chinese residents are lower and do not need to be paid attention to.
【作者单位】：国家食品安全风险评估中心;
【基金】：国家科技支撑计划(2012BAK01B01)
【分类号】：R114
【正文快照】： 毒理学关注阈值(threshold of toxicologicalconcern,TTC)决策树方法是一种有效的风险评估工具,可用于食品接触材料的优先筛选和初步评估[1]。它对某类型的化学物暴露水平限定一个阈值,低于该阈值以下的慢性暴露,可以被认为终身暴露没有可观察到的健康风险[2]。邻苯二甲酸酯

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