客家娘酒对衰老小鼠免疫功能及抗氧化的影响

发布时间：2018-01-17 14:19

本文关键词：客家娘酒对衰老小鼠免疫功能及抗氧化的影响　出处：《食品科技》2017年08期 　论文类型：期刊论文

【摘要】：目的:研究客家娘酒对D-半乳糖所致亚急性衰老小鼠抗氧化能力及免疫功能的影响。方法:采用腹腔注射D-半乳糖建立亚急性衰老小鼠模型,分别灌胃蒸馏水和不同浓度的黄酒,每天1次,连续灌胃45 d,测定小鼠肝、脑中的超氧化物歧化酶(Superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)活性,丙二醛(Malondialdehyde,MDA)含量,血清白细胞介素6(Interleukin-6,IL-6)、肿瘤坏死因子α(Tumor necrosis factorα,TNF-α)以及胸腺、脾脏指数。结果:客家娘酒能显著提高衰老小鼠肝脏、脑SOD、GSH-Px活性,降低肝脏、脑中的MDA含量,能显著抑制衰老小鼠胸腺和脾脏指数的下降,显著降低血清IL-6、TNF-α水平。结论:客家娘酒具有增强衰老小鼠抗氧化能力以及调节免疫功能的作用。
[Abstract]:Objective: to study the effect of Hakka Niang wine on anti-oxidation ability and immune function of subacute aging mice induced by D-galactose. Methods: subacute aging mice model was established by intraperitoneal injection of D-galactose. Superoxide dismutase (dismutase) in liver and brain of mice were measured by intragastric administration of distilled water and rice wine of different concentrations once a day for 45 days. The activity of glutathione peroxidase (Glutathione peroxidase) GSH-Px and malondialdehyde (malondialdehyde). The content of MDAs, serum interleukin 6, interleukin 6, tumor necrosis factor 伪 (Tumor necrosis factor 伪), and tumor necrosis factor 伪 (TNF- 伪) were measured. Results: Hakka Niang Liquor could significantly increase the activity of GSH-Px in liver and brain of aging mice and decrease the content of MDA in liver and brain. It could significantly inhibit the decrease of thymus and spleen index and serum IL-6 in aging mice. Conclusion: Hakka Niang Liquor can enhance the antioxidation ability and regulate the immune function of aging mice.
【作者单位】：嘉应学院医学院;梅州市人民医院;
【基金】：广东省创新强校工程课题(20141275) 全国大学生创新创业训练计划项目(201510582020) 梅州市产业研究与技术开发资金项目(201411) 广东省医学科学基金项目(B2016062)
【分类号】：R151.3;TS262.4
【正文快照】： 黄酒是我国特有的传统酒,历史悠久,和啤酒、葡萄酒并列为世界三大酿造酒,具有独特的风味和保健功能。根据酿造原料的不同,黄酒又可以分为黍米黄酒、麦曲黄酒和红曲黄酒等多个种类,不同品种黄酒间风味、成分以及保健功效均相似性和差异性并存[1]。近年来对黄酒保健功效的研究逐

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