东北地区青年人群尿液中邻苯二甲酸酯代谢物的残留和健康风险评价

发布时间：2018-01-22 23:40

本文关键词： 邻苯二甲酸酯代谢物尿液青年人群暴露评估东北地区　出处：《黑龙江大学自然科学学报》2015年05期 　论文类型：期刊论文

【摘要】：为了了解东北地区青年人群体内邻苯二甲酸酯(PAEs)的暴露水平,在黑龙江、吉林和辽宁省共采集了25个青年人群尿液样品,采用高效液相色谱—质谱联用仪(HPLC-MS/MS)分析了尿液样品中10种PAEs代谢物的浓度水平。结果表明,东北地区青年人群尿液中PAEs代谢物的残留非常普遍,黑龙江、吉林和辽宁省青年人群尿液中PAEs代谢物的总浓度分别为114、495和422ng·m L-1。不同省份青年人群尿液中PAEs代谢物的组成特征不同,mi BP、m BP和DEHP分别为黑龙江、吉林和辽宁省青年人群尿液中浓度比例最大的代谢物。东北地区青年人群体内单个PAE的暴露量均小于容许参考暴露剂量,但是,吉林和辽宁省部分青年人群体内PAEs的总暴露危险指数超过了人体PAEs的累积风险阈值,可能存在健康风险。
[Abstract]:In order to understand the exposure level of PAEs in Northeast China, 25 urine samples were collected in Heilongjiang, Jilin and Liaoning provinces. The concentrations of 10 PAEs metabolites in urine samples were determined by high performance liquid chromatography-mass spectrometry (HPLC-MS / MS). The residues of PAEs metabolites in urine of young people in Northeast China were very common. The total concentrations of PAEs metabolites in urine of young people in Heilongjiang, Jilin and Liaoning provinces were 114, respectively. 495 and 422ng 路ml -1. The composition characteristics of PAEs metabolites in urine of young people in different provinces were different. The composition of BPP-MBP and DEHP in urine of young people in different provinces were Heilongjiang, respectively. Young people in Jilin and Liaoning Province had the highest concentration of metabolites in urine. The exposure of single PAE in the young people in Northeast China was lower than the allowable reference exposure dose, but. The total exposure risk index of PAEs in some young people in Jilin and Liaoning Province exceeded the cumulative risk threshold of human PAEs, which may lead to health risk.
【作者单位】：哈尔滨工业大学市政环境工程学院城市水资源与水环境国家重点实验室国际持久性有毒物质联合研究中心;
【基金】：国家自然科学基金资助项目(21277038) 城市水资源与水环境国家重点实验室(哈尔滨工业大学)自主课题(2013DX14)
【分类号】：R114;O657.63
【正文快照】： 0引言邻苯二甲酸酯(PAEs)是一类普遍存在的环境激素类污染物,最初主要作为增塑剂应用于聚乙烯、聚丙烯、聚氯乙烯、聚苯乙烯等材料的生产,用以改良材料的强度和柔韧性。随着增塑剂使用的日渐广泛,长链PAEs如邻苯二甲酸二(2-乙基己基)酯(DEHP)主要应用于PVC产品、塑溶胶、聚乙

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