吸附无细胞百白破联合疫苗加强免疫与水痘减毒活疫苗联合接种的效果观察

发布时间：2018-01-24 00:33

本文关键词： 无细胞百白破联合疫苗加强免疫免疫原性水痘减毒活疫苗　出处：《中国疫苗和免疫》2017年02期 　论文类型：期刊论文

【摘要】：目的评价吸附无细胞百白破联合疫苗(Diphtheria,tetanus and acellular pertussis combined vaccine,DTaP)加强免疫单独接种和同时接种水痘减毒活疫苗(Varicella attenuated live vaccine,VarV)的免疫效果。方法选取满18月龄且已完成DTaP基础免疫的健康儿童218名,其中110人接种DTaP,108人同时接种DTaP和VarV。采用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)检测免疫前、后抗百日咳毒素抗体(Antibody to pertussis toxin,Anti-PT)、抗丝状血凝素抗体(Antibody to filamentous hemagglutmin,Anti-FHA)、抗白喉毒素抗体(Antibody to diphtheria toxin,Anti-DT)和抗破伤风毒素抗体(Antibody to tetanus toxin,Anti-TT),计算抗体几何平均浓度(Geometric Mean Concentration,GMC)和抗体阳转率(Seroconversion rate,SCR)。结果单独接种组和同时接种组免疫后Anti-PT、Anti-FHA、Anti-DT和Anti-TT的SCR分别为43.64%、81.48%(x~2=33.26,P=0.000),72.73%、85.19%(x~2=0.84,P=0.358),90.00%、85.18%(x~2=1.16,P=0.281),13.64%、11.11%(x~2=0.32,P=0.571);GMC分别为94.74IU/ml、98.86IU/ml(t=1.15,P=0.251),39.59IU/ml、44.10IU/ml(t=1.90,P=0.059),1.89IU/ml、1.47IU/ml(t=3.83,P=0.000),3.85IU/ml、2.72IU/ml(t=5.51,P=0.000)。两组Anti-PT、Anti-FHA免疫前阴性者免疫后SCR高于免疫前阳性者。同时接种组免疫后Anti-PT、Anti-FHA的GMC增长高于单独接种组,而免疫后Anti-DT、Anti-TT的GMC增长低于单独接种组。结论 DTaP加强免疫对预防百日咳的保护力有限,对预防白喉、破伤风的加强免疫时间可以延长,同时接种DTaP和VarV对DTaP的免疫原性无影响。
[Abstract]:Objective to evaluate the adsorption of acellular diphtheria vaccine. Tetanus and acellular pertussis combined vaccine. DTaP) was immunized with varicella attenuated live vaccine and vaccinated with varicella attenuated live vaccine. Methods 218 healthy children over 18 months old who had completed the basic immunization of DTaP were selected and 110 of them were vaccinated with DTaP. Both DTaP and Varv.Enzyme-linked immunosorbent assay were detected by enzyme-linked immunosorbent assay (Elisa). Elisa was used to detect antibody to pertussis toxin anti-PTT before and after immunization. Antibody to filamentous hemagglutinin Anti-FHA. Antibody to diphtheria toxin. Anti-DT) and anti-tetanus toxin antibody Antibody to tetanus toxin Anti-TTT. Geometric Mean Concentration was calculated. GMC) and seroconversion rate were determined. Results Anti-PTT Anti-FHA was immunized only in the inoculation group and at the same time. The SCR of Anti-DT and Anti-TT were 43.64% and 72.73% respectively. 85.19 the ratio of 0.358U / 0.358U / 0.358U / 0.358U / t / 85.19 is 85.18 / 85.18 / 1.16 / 0.281 / 0.281 / 0.284% / 13.64% respectively. 11.11 0.32U 0.571C; The GMC was 94.74 IUU / ml and 98.86 IUP / ml respectively. 44.10 IUU / ml ~ (1.90) P ~ (0.059) ~ (1.89) ~ (?) ~ (1.47) ~ (?) ~ (3.83) ~ (?) ~ (0.000). 3.85IUP / ml 2.72IUP / ml 5.51Pu 0.000. two groups of Anti-PT. After immunization, the SCR of Anti-FHA negative group was higher than that of pre-immunization positive group, and the increase of GMC of Anti-PTT Anti-FHA was higher in the inoculation group than in the single inoculation group. But the increase of GMC in Anti-DTT Anti-TT after immunization was lower than that in single inoculation group. Conclusion the protective effect of DTaP on prevention of pertussis is limited and diphtheria can be prevented. The time of enhanced immunization of tetanus could be prolonged, and inoculation of DTaP and VarV had no effect on the immunogenicity of DTaP.
【作者单位】：衢州市疾病预防控制中心;浙江省疾病预防控制中心;
【基金】：衢州市科技局项目(2015102)
【分类号】：R186
【正文快照】： 百日咳、白喉分别是由百日咳鲍特菌(Borde-tella pertussis)和白喉杆菌(Bacillus diphtheria)感染引起的急性呼吸道传染病,通过飞沫传播,传染性极强[1]。破伤风是感染性细菌性疾病,由破伤风痉挛毒素引发肌肉强直和痉挛,病死率较高,主要发生于不洁分娩和产后卫生条件较差的新生

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