花椒精对卵巢切除大鼠脂质代谢的影响

发布时间：2018-02-16 15:29

本文关键词： 花椒精卵巢切除大鼠血脂胆汁酸中性固醇　出处：《食品科学》2015年05期 　论文类型：期刊论文

【摘要】：目的:探讨花椒精对卵巢切除大鼠脂质代谢的影响。方法:将40只雌性Sprague-Dawley(SD)大鼠随机分为5组,其中1组进行伪切除手术(Sham)作为对照组,另外4组进行双侧卵巢切除手术(ovariectomy,OVX),恢复饲喂一周后,分为空白组和灌胃花椒精高(15 mg/kg)、中(10 mg/kg)、低(5 mg/kg)剂量组。灌胃4周后解剖,检测大鼠血脂、肝脂及小肠和粪便中胆汁酸含量等指标。结果:灌胃花椒精可降低血清中甘油三酯(triglyceride,TG)、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)和非高密度脂蛋白胆固醇(non-high density lipoprotein cholesterol,non-HDL-C)的浓度(P0.05),升高HDL-C的浓度;降低肝脏中脂肪、TC、TG的含量(P0.05);增加大鼠排便量、促进小肠内容物和粪便中胆汁酸以及粪醇、胆固醇等中性固醇的排泄,且存在明显的剂量效应。结论:花椒精可改善卵巢切除SD大鼠因雌性激素缺乏而引起的高脂血症,可能与促进胆汁酸和中性固醇的排泄有关。
[Abstract]:Objective: to investigate the effect of prickly ash extract on lipid metabolism in ovariectomized rats. Methods: forty female Sprague-Dawley SD rats were randomly divided into five groups, one of which was treated with pseudo-resection. The other four groups underwent bilateral ovariectomytomy OVX, and were divided into blank group and 15 mg / kg group, 10 mg / kg, 5 mg / kg) group, then dissected after 4 weeks of gastric administration, and then measured the blood lipid, and measured the blood lipid of the rats after 4 weeks of gastric administration. The rats were fed with the same dosage of Zanthoxylum prunbergium at a dose of 15 mg / kg, 10 mg / kg, and 5 mg / kg respectively. Liver fat and bile acid contents in small intestine and feces. Results: Zanthoxylin could reduce serum triglyceride-triglyceride-TGG, total cholesterol cholesterol total cholesterol cholesterol, low density lipoprotein cholesterol in LDL-C, and non-high density lipoprotein of non-high density lipoprotein cholesterol. The concentration of HDL-C was increased by the concentration of P0. 05% in cholesterolus non-HDL-C; Decrease the content of TCN TG in liver, increase the excretion of rat defecation, promote the excretion of bile acid, fecal acid, fecal alcohol, cholesterol and other neutral steroids in small intestine and feces. Conclusion: Zanthoxylin can improve hyperlipidemia induced by estrogen deficiency in ovariectomized SD rats, which may be related to promoting the excretion of bile acid and neutral steroids.
【作者单位】：西南大学食品科学学院;重庆文理学院林学与生命科学学院;
【基金】：国家自然科学基金面上项目(NSFC 31171679) 重庆市科学技术基金项目(CSTC2010BB1350)
【分类号】：R151

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