QuEChERS结合气相色谱-质谱法快速测定职业工人尿液中多溴联苯醚

发布时间：2018-02-24 09:13

本文关键词： 多溴联苯醚尿液气相色谱-质谱(GC-MS) 职业工人　出处：《分析测试学报》2017年05期 　论文类型：期刊论文

【摘要】：建立了QuEChERS前处理结合气相色谱-质谱快速测定职业工人尿液中8种多溴联苯醚同系物的分析方法。尿液样在氯化钠和无水硫酸镁的脱水与盐析作用下以正己烷-丙酮混合液提取,采用C18去除提取液中的杂质,并采用气相色谱-负化学源质谱法在选择离子监测模式下测定,内标法定量。三至七溴联苯醚在1~100 pg/μL(十溴联苯醚为10~1 000 pg/μL)范围内线性关系良好,相关系数均大于0.999。待测物在3个加标水平下的平均回收率为91.7%~110.2%,相对标准偏差(RSD)小于10%。多溴联苯醚的检出限为0.3~36 pg/m L。该方法简单快速,灵敏度和选择性较高,适合职业工人体内污染物暴露水平监测。
[Abstract]:A method for the rapid determination of eight polybrominated diphenyl ether congeners in the urine of occupational workers by QuEChERS pretreatment combined with gas chromatography-mass spectrometry was established. The urine samples were dehydrated by sodium chloride and anhydrous magnesium sulfate and salted out with hexane. Acetone mixture extraction, C18 was used to remove impurities in the extract, and gas chromatography-negative chemical source mass spectrometry was used to determine it in a selective ion monitoring mode. The linear range of three to seven brominated diphenyl ethers (decabromodiphenyl ether was 10 ~ 1 000 PG / 渭 L) in the range of 1 ~ 100 PG / 渭 L was determined by the internal standard method. The relative standard deviation (RSD) was less than 10. The detection limit of PBDEs was 0.3 ~ 36 pg/m / L. the method was simple, rapid, sensitive and selective. Suitable for monitoring the exposure level of pollutants in occupational workers.
【作者单位】：山东省职业卫生与职业病防治研究院检验科;山东省疾病预防控制中心;首都医科大学公共卫生学院;
【基金】：国家自然科学基金(21477083) 山东省医药卫生科技发展计划项目(2013WS0159) 首都医科大学校自然科学基金(2016ZR01) 北京市自然科学基金(7122022)
【分类号】：O657.63;R13

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