正己烷雌性生殖毒性及其内分泌干扰作用研究进展

发布时间：2018-03-05 06:28

本文选题：正己烷　切入点：-己二酮　出处：《中国职业医学》2016年02期 　论文类型：期刊论文

【摘要】：正正己烷属饱和脂肪烃类,广泛应用于黏胶、电子器件清洗、印刷、干洗、家具、运动器材及制鞋等行业中,主要通过呼吸道和胃肠道等途径进入人体,分布于脂肪含量高的组织,对中枢神经系统有抑制作用,长期接触可致多发性周围神经病变。2,5-己二酮(2,5-Hexadione,2,5-HD)是正己烷的主要代谢产物,属γ-二酮类化合物,目前被认为是正己烷毒性的关键物质。近年来正己烷毒性研究主要集中在神经毒理学
[Abstract]:N-hexane is a saturated fatty hydrocarbon, widely used in viscose, electronic device cleaning, printing, dry cleaning, furniture, sports equipment and shoe making industries, mainly through the respiratory tract and gastrointestinal tract, etc. Distributed in tissues with high fat content, it has an inhibitory effect on the central nervous system. Long-term exposure may lead to multiple peripheral neuropathy. The main metabolites of n-hexane, I. e., 纬 -diketones, are the main metabolites of n-hexane. At present, it is considered as the key substance of n-hexane toxicity. In recent years, the study of n-hexane toxicity is mainly focused on neurotoxicology.
【作者单位】：广东药科大学公共卫生学院;深圳市宝安区福永卫生监督所;
【分类号】：R114

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