上海市152对乳母婴儿尿中邻苯二甲酸酯累积暴露的风险评估

发布时间：2018-03-08 03:34

  本文选题：邻苯二甲酸酯类物质代谢产物　切入点：邻苯二甲酸二(-乙基己基)酯　出处：《卫生研究》2017年02期 　论文类型：期刊论文

【摘要】：目的通过尿中邻苯二甲酸酯类(phthalates)代谢物浓度估计上海市乳母和婴儿邻苯二甲酸酯类的暴露水平,并对其累积暴露进行健康风险评估。方法采用横断面调查方法,对152对乳母和婴儿进行问卷调查和一次性随机尿样采集。使用液相色谱-串联质谱法检测乳母和婴儿尿液中的10种邻苯二甲酸酯类代谢物浓度。使用肌酐校正模型对6种邻苯二甲酸酯类进行暴露评估。使用危害指数法进行累积风险评估。结果乳母尿中邻苯二甲酸酯类代谢产物浓度检出水平前5位分别为邻苯二甲酸单异丁酯(mono-isobutyl phthalate,Mi BP)、邻苯二甲酸单正丁酯(monon-butyl phthalate,Mn BP)、邻苯二甲酸单乙酯(mono-ethyl phthalate,MEP)、邻苯二甲酸单甲酯(mono-methyl phthalate,MMP)和邻苯二甲酸单(2-乙基己基)酯(mono-2-ethylhexyl phthalate,MEHP);婴儿则分别为Mi BP、Mn BP、MEP、MEHP和单(2-乙基-5-羧基戊基)邻苯二甲酸酯(mono-2-ethyl-5-carboxypentyl phthalate,MECPP)。以尿中邻苯二甲酸酯类代谢产物来估算邻苯二甲酸酯类的每日暴露量(estimated daily intake,EDI),邻苯二甲酸二(2-乙基己基)酯(di-2-ethylhexyl phthalate,DEHP)在乳母和婴儿中均浓度最高,几何均值分别达到6.64和14.02μg/(kg·d),其他邻苯二甲酸酯类在乳母和婴儿中的EDI值从高到低邻苯二甲酸二异丁酯(di-i-sobutyl phthalate,Di BP)和邻苯二甲酸二正丁酯(di-n-butyl phthalate,Dn BP)、邻苯二甲酸二乙酯(diethyl phthalate,DEP)、邻苯二甲酸二甲酯(di-methyl phthalate,DMP)和邻苯二甲酸丁基苄酯(butyl-benzyl phthalate,BBP)。采用危害指数法(hazard index,HI)评估累积暴露风险,乳母HI≥1的比例约为5.92%,婴儿HI≥1的比例约为32.24%。结论上海市乳母和婴儿接触邻苯二甲酸酯类存在一定的健康风险,婴儿的风险高于乳母。
[Abstract]:Objective to estimate the exposure levels of phthalates in the urine of lactating mothers and infants in Shanghai and to assess the health risk of their cumulative exposures. A questionnaire survey was conducted in 152 nursing mothers and infants and a single random urine sample was collected. The concentrations of 10 phthalate metabolites in the urine of lactating mothers and infants were determined by liquid chromatography-tandem mass spectrometry. Creatinine calibration model was used. The cumulative risk was assessed by hazard index method. Results the first five levels of phthalate metabolites in the urine of lactating mother were found to be monomethyl phthalate. Mono-isobutyl phthalate (Mi BPN), monon-butyl phthalate (n-butyl phthalate), mono-ethyl phthalate (MBP), mono-ethyl phthalate (MEPN), mono-methyl phthalate (MMPP) and mono-2-ethylhexyl phthalyl phthalyl phthalate (MEHPN) in infants; and in infants, Mi BPg-Mn BP- MEPMEPMEHP and mono-2-ethylhexyl phthalate (MEHPHPU), respectively, and mono-methyl phthalate mono-methyl phthalate (MMPP) and mono-2-ethylhexyl phthalyl phthalyl phthalate (MEHPN); in infants, the mono-2-ethylhexyl phthalate mono-2-ethylhexyl phthalate (M2-ethylhexyl) phthalate is mono-2-ethylhexyl phthalate; Pentyl) phthalate mono-2-ethyl-5-carboxypentyl phthalate phthalate (MECPPN). The daily exposure of phthalates to phthalates was estimated by the metabolites of phthalates in urine. The concentrations of di-2-ethylhexyl phthalate di-2-ethylhexyl phthalate (DEHP) were the highest in both mother and infant. The geometric mean values were 6.64 and 14.02 渭 g / kg 路dl, respectively. The EDI values of other phthalates in nursing mothers and infants ranged from high to low, and di-i-sobutyl phthalate Di BPs, di-n-butyl phthalate di-n-butyl phthalateDn BP-, diethyl phthalate diethyl phthalate, diethyl phthalate, diethyl phthalate, diethyl phthalate, diethyl phthalate, dibutyl phthalate, dibutyl phthalate, diethyl phthalate, diethyl phthalate, diethyl phthalate, dibutyl phthalate, Dimethyl phthalate (DMP) and Ding Ji benzyl phthalate phthalate (BBP) were used to assess the cumulative exposure risk. The ratio of HI 鈮，

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