亲代三丁基锡暴露对F1代KM小鼠血常规的影响

发布时间：2018-03-18 13:17

本文选题：三丁基锡　切入点：小鼠　出处：《中国比较医学杂志》2015年05期 　论文类型：期刊论文

【摘要】：目的探讨亲代三丁基锡暴露对F1昆明小鼠血常规的影响。方法将雌、雄各40只小鼠随机分别分为空、低、中、高浓度组(0、0.2、2和20μg/kg),每天进行染毒,持续45 d。在第60天时,将同浓度组的雌:雄鼠按1:1进行同笼配种。仔鼠出生60 d后取血,进行血常规的检测。结果与对照组相比,F1代雄性低浓度和高浓度组的红细胞数量和血红蛋白量显著增加(P0.01);F1代雄性低浓度组红细胞体积、平均血红蛋白含量(P0.01)和淋巴细胞绝对值(P0.05)显著降低;F1代雌性高浓度组的红细胞数量显著增加(P0.01),F1代雌性小鼠的血红蛋白量、红细胞压积、血小板量三项指标随着TBT浓度的增加呈剂量依赖性。结论亲代TBT暴露影响F1代小鼠的血常规,且低浓度时对F1代雄性小鼠的影响最大,高浓度时对F1代雌性小鼠的影响最大。
[Abstract]:Objective to investigate the effect of exposure to tin from three Ding Ji parents on blood routine examination of F1 Kunming mice. Methods Forty female mice and 40 male mice were randomly divided into three groups: empty, low, middle and high concentration groups, 0.2 and 20 渭 g 路kg ~ (-1) 路kg ~ (-1) respectively, exposed daily for 45 days. The male and female mice of the same concentration group were bred in the same cage according to 1: 1. The blood was taken from the offspring 60 days after birth. Results compared with the control group, the red blood cell number and hemoglobin content in the male low concentration and high concentration group significantly increased the volume of red blood cell in the male low concentration group. The mean hemoglobin content (P0.01) and the absolute value of lymphocytes (P0.05) significantly decreased the number of red blood cells (RBC) significantly increased the hemoglobin content and hematocrit of the female mice of P0.01 + F _ 1 generation in the female F _ 1 generation of F _ 1 generation. Conclusion the blood routine of F1 generation mice was affected by TBT exposure of parents, and the effect of low concentration on F1 generation male mice was the greatest, and that of high concentration on F1 generation female mice was the biggest. [WT5HZ] [WT5 "BZ] [WT5" BZ] [WT5 "BZ] [WT5" BZ] [WT5BZ]
【作者单位】：河南科技大学动物科技学院;
【基金】：河南科技大学SRTP项目(2014264)
【分类号】：R114

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