氨糖胶囊的急性和亚急性毒理学评价

发布时间：2018-03-22 00:17

本文选题：急性毒性　切入点：MTD　出处：《食品研究与开发》2015年14期 　论文类型：期刊论文

【摘要】：氨糖胶囊系由氨基葡萄糖盐酸盐、硫酸软骨素、碳酸钙和维生素D组成的具有增加骨密度功能的保健食品,为判定其对人体健康是否产生危害,特进行了安全性毒理学评价。依据《食品安全性毒理学评价程序》,对氨糖胶囊进行了急性毒性试验和30 d喂养试验。结果表明,氨糖胶囊对雌、雄小鼠的急性经口的最大耐受剂量(MTD)大于20.0 g/kg·bw,根据急性毒性分级,氨糖胶囊属无毒级。连续氨糖胶囊喂养30天,各剂量组动物生长良好,体重、进食量及食物利用率、血液学指标、血生化指标、脏器绝对重量及脏/体比值与阴性对照组相比均无显著差异(P0.05);病理组织学检查结果也表明氨糖胶囊对受检脏器无明显损害。因此,根据实验结果,判定氨糖胶囊为安全性保健食品
[Abstract]:The capsule is a health food consisting of glucosamine hydrochloride, chondroitin sulfate, calcium carbonate and vitamin D, which can increase bone mineral density. According to the procedure of Food Safety Toxicology evaluation, acute toxicity test and 30-day feeding test were carried out on ammonia sugar capsule. The results showed that ammonia sugar capsule was effective to female, The maximum tolerated dose (MTD) of male mice was greater than 20.0 g/kg BW. According to the acute toxicity classification, ammonia sugar capsule was classified as nontoxic. After 30 days of continuous feeding with ammonia sugar capsule, the animals in each dose group grew well, their body weight, food intake and food utilization rate were good. There was no significant difference in hematological index, blood biochemical index, viscera absolute weight and viscera / body ratio compared with the negative control group (P 0.05). The histopathological results also showed that ammonia Tang capsule had no obvious damage to the tested organs. Therefore, according to the experimental results, Determination of Ammonosaccharide capsule as a safe and healthy Food
【作者单位】：江苏省中国科学院植物研究所药用植物研究开发中心;江苏省农业种质资源保护与利用平台;福建省肿瘤医院;广西嘉盈生物科技有限公司;托尔专用化学品(镇江)有限公司;
【分类号】：R114;TS218

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