瑞士乳杆菌TS206对小鼠血脂及粪便胆汁酸水平的调控影响

发布时间：2018-04-09 08:54

本文选题：瑞士乳杆菌TS　切入点：血脂　出处：《食品科学》2017年11期

【摘要】：探讨瑞士乳杆菌TS206(Lactobacillus helveticus TS206)对小鼠血脂水平的影响。以健康BABL/c小鼠为对象,设置实验组和对照组,分别以L.helveticus TS206菌悬液和生理盐水(0.2 m L/d)连续灌胃7周,监测小鼠体质量和血脂(总胆固醇(total serum cholesterol,TC)、甘油三酯(triglycerides,TG)水平、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)和低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C))以及粪便总胆汁酸(total bile acid,TBA)水平的变化。灌胃L.helveticus TS206后,小鼠体质量增量显著高于对照组(P0.05,P0.01);血清中TC、TG和LDL-C水平均显著降低(P0.05),灌胃停止1周后基本恢复到对照组水平;L.helveticus TS206菌悬液和生理盐水小鼠血清中HDL-C含量均无显著性变化;TBA水平呈先下降后上升趋势,且3周后TBA水平显著低于对照组(P0.05)。研究结果表明,L.helveticus TS206能促进健康小鼠体质量增加,并有效调控其血脂水平,提示口服L.helveticus TS206菌剂可能会降低患心脑血管疾病的风险。
[Abstract]:To investigate the effect of Lactobacillus TS206(Lactobacillus helveticus TS206 on blood lipid levels in mice.Healthy BABL/c mice were divided into experimental group and control group. The mice were perfused with L.helveticus TS206 suspension and normal saline 0.2 mL / d for 7 weeks, respectively. The body weight and serum lipids (TGs) of the mice were monitored.Changes of high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-CU) and total total bile acid (total bile acidine) in feces.After intragastric administration of L.helveticus TS206,The body weight increment of mice was significantly higher than that of the control group (P 0.05, P 0.01), and the levels of serum TCU TG and LDL-C were significantly lower than those of the control group. After one week of gastric administration, the levels of HDL-C in the serum of mice with L.helveticus TS206 and normal saline were basically restored to the control level. There was no significant change in HDL-C content in the serum of mice with normal saline and the suspension of L.helveticus TS206.The level of TBA decreased first and then increased.After 3 weeks, the level of TBA was significantly lower than that of control group (P 0.05).The results showed that L.helveticus TS206 could promote the increase of body mass and regulate the blood lipid level of healthy mice, suggesting that oral L.helveticus TS206 could reduce the risk of cardiovascular and cerebrovascular diseases.
【作者单位】：天津市食品生物技术重点实验室天津商业大学生物技术与食品科学学院;
【基金】：国家自然科学基金面上项目(31071522) 天津市科技创新体系及条件平台建设项目(100005)
【分类号】：R151

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