上海市闵行区某民办中学聚集性肺结核疫情分析

发布时间：2018-04-09 22:40

本文选题：肺结核　切入点：聚集性疫情　出处：《复旦学报(医学版)》2017年05期

【摘要】：目的分析上海市闵行区某民办中学一起肺结核聚集性疫情发生的情况。方法对该校高三年级师生进行症状和摄片筛查,对疑似患者开展流行病学问卷调查,开展痰涂片、细菌培养及分子流行病学检测,并对阳性菌株进行全基因组测序。结果该校高三某班1例肺结核患者(指示病例)的49名校内密切接触者中确诊肺结核10例,其中痰检阳性3例;扩大筛查范围时又确诊1例,且痰检阳性。针对指示病例和筛查发现的4例痰检阳性患者,分离培养的菌株基因型与该班前一年首发病例相同,指示有相互传播的可能。结论本次疫情属于聚集性爆发疫情,可能由首发病例所导致。及时确诊和有效治疗学生肺结核患者,并对其密切接触者及时进行肺结核筛查,对控制学校肺结核爆发具有重要意义。
[Abstract]:Objective to analyze the incidence of pulmonary tuberculosis in a private middle school in Minhang District, Shanghai.Methods the students and teachers of grade 3 were screened for symptoms and films, the suspected patients were investigated with epidemiological questionnaire, sputum smear, bacterial culture and molecular epidemiology were detected, and the whole genome of the positive strains was sequenced.Results 10 of 49 patients with pulmonary tuberculosis (indication case) in a class of senior high school were diagnosed, of which 3 were sputum positive, and 1 was positive in sputum examination when expanding the scope of screening.For the indicative cases and 4 sputum positive patients, the genotypes of the isolated and cultured strains were the same as those of the first cases in the previous year, indicating the possibility of mutual transmission.Conclusion this epidemic is a cluster outbreak, which may be caused by the first case.Timely diagnosis and effective treatment of students with pulmonary tuberculosis, and close contact with the timely screening of tuberculosis, to control the outbreak of pulmonary tuberculosis in schools is of great significance.
【作者单位】：上海市闵行区疾病预防控制中心;上海市疾病预防控制中心;复旦大学公共卫生学院流行病学教研室;
【基金】：上海市公共卫生与预防医学Ⅰ类高峰学科建设计划~~
【分类号】：R181.3;R521

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