某铅锌矿区职业人群体内锌、镉负荷及脂质过氧化物酶水平

发布时间：2018-04-10 10:02

本文选题：铅锌矿区　切入点：职业人群　出处：《环境与职业医学》2015年09期

【摘要】：[目的]探讨铅锌矿区职业人群体内锌、镉负荷及脂质过氧化物酶的含量。[方法]采用横断面流行病学研究方法,对146名某矿区作业工人和54名非矿区人群进行健康检查和现场采集发样及血样,检测其发镉、发锌、血镉、血锌及血清脂质过氧化酶超氧化物歧化酶(T-SOD)、丙二醛(MDA)及谷胱甘肽氧化酶(GSH-Px)的水平,并进行统计学分析。[结果]接触组发锌、发镉、血镉均高于对照组(P0.01或P0.05),血锌、T-SOD、GSH-Px活性均低于对照组(P0.01或P0.05);接触组MDA水平与对照组差异无统计学意义(P0.05)。接触组中工龄≤10年者,其发镉及血镉水平均低于工龄11年以上者,差异有统计学意义(P0.05)。[结论]铅锌矿区职业人群长期接触镉后可改变体内T-SOD、GSH-Px、MDA水平,导致矿区职业人群体内脂质过氧化作用增强,抗氧化能力降低。
[Abstract]:[objective] to study the contents of zinc, cadmium and lipid peroxidase in the occupational population in lead and zinc mining area.[methods] A cross-sectional epidemiological study was carried out on 146 workers and 54 non-mining workers in a mining area. Hair cadmium, hair zinc and blood cadmium were detected.The levels of serum zinc and serum lipid peroxidase superoxide dismutase (T-SOD), malondialdehyde (MDAA) and glutathione oxidase (GSH-Px) were analyzed statistically.[results] the levels of hair zinc, hair cadmium and blood cadmium in the exposed group were higher than those in the control group (P0.01 or P0.05A), and the activities of GSH-Px in the blood zinc monoxide (T-SODN) were lower than those in the control group (P0.01 or P0.05A), but the level of MDA in the exposed group was not significantly different from that in the control group (P 0.05).In the exposed group, the levels of hair cadmium and blood cadmium were lower than those of more than 11 years of service (P 0.05).[conclusion] after exposure to cadmium for a long time, the level of GSH-PxN MDA in the body of the occupational population in lead-zinc mining area can be changed, which leads to the increase of lipid peroxidation and the decrease of antioxidant capacity in the body of the occupational population in the mine area.
【作者单位】：大理学院公共卫生学院;常德市疾病预防控制中心;兰坪县疾病预防控制中心;
【分类号】：R131

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