美藤果油辅助改善小鼠记忆的功效

发布时间：2018-04-12 22:10

  本文选题：美藤果油 + 改善记忆　； 参考：《食品科学》2017年09期

【摘要】：目的:通过小鼠实验探讨美藤果油改善记忆功能的作用。方法:72只雄性SPF级昆明小鼠随机分为空白组,模型组,美藤果油低、中、高剂量组(375.1、750.2、1 500.0 mg/(kg·d),以体质量计,下同)及深海鱼油组(1 500.0 mg/kg)。连续给药30 d后,进行避暗、跳台、Morris水迷宫实验。结果:美藤果油750.2、1 5 0 0.0 mg/(k g·d)剂量组能剂量依赖性地显著延长模型小鼠避暗和跳台实验的潜伏期,减少错误次数(P0.05),而对Morris水迷宫测试中的潜伏期及游泳路程百分比无显著影响。结论:美藤果油在375.1~1 500.0 mg/(kg·d)的剂量范围内可能具有辅助改善小鼠记忆功能的作用。
[Abstract]:Objective: to study the effect of malleol on memory function in mice.Methods Seventy-two male Kunming mice of SPF grade were randomly divided into blank group, model group, low, medium and high dose group (375.1750.2 ~ 1 500.0 mg/(kg DX) and deep-sea fish oil group (1 500.0 mg 路kg ~ (-1) 路kg ~ (-1) ~ (-1) mg 路kg ~ (-1)).After 30 days of continuous administration, the water maze test was carried out.Results: the dose group of 750.2 and 1500.0 mg/(k / d could significantly prolong the latency of dark avoidance and platform jumping test in model mice in a dose-dependent manner, and reduce the number of errors (P0.05), but had no significant effect on the latency and the percentage of swimming distance in Morris water maze test.Conclusion: in the range of 375.1 ~ 1 ~ (-1) mg/(kg ~ (-1) mg/(kg ~ (-1) ~ (-1) ~ (-1) mg/(kg ~ (-1) ~ (-1) ~ (-1) ~ (-1) mg/(kg ~ (-1),
【作者单位】： 沈阳药科大学生命科学与生物制药学院;
【分类号】：R151
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