不同时间点应用米索前列醇对无痛人流术患者手术指标及丙泊酚用量的影响

发布时间：2018-04-18 23:40

本文选题：米索前列醇 + 无痛人流术　；参考：《中国药房》2015年03期

【摘要】：目的:观察不同时间点应用米索前列醇对无痛人流术患者手术指标及丙泊酚用量的影响。方法:选取宫内早孕以无痛人流术终止妊娠的患者202例,按随机数字表法分为A、B、C组(65、71、66例),分别于术前30、60、90 min口服米索前列醇片0.4mg。观察3组患者的宫颈松弛程度、手术时间、术前和术中出血量、术后子宫收缩情况、丙泊酚诱导负荷量和总使用量及不良反应等。结果:B、C组患者宫颈松弛率比较差异无统计学意义(P0.05),而B、C组患者宫颈松弛率均显著高于A组(P0.05);B组患者手术时间显著短于A、C组(P0.05);B组患者术前出血量与A组相似(P0.05),A、B组患者术前出血量均显著少于C组(P0.05);患者术中出血量B组A组C组(P0.05);患者术后子宫收缩优良率B组C组A组(P0.05);患者丙泊酚诱导负荷量及总使用量B组C组A组(P0.05);3组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:术前60 min应用米索前列醇相比术前30、90 min应用具有更理想的效果和相似的安全性,并可减少丙泊酚用量。
[Abstract]:Aim: to observe the effect of misoprostol on surgical indexes and propofol dosage in painless abortion patients at different time points.Methods: 202 cases of early intrauterine pregnancy terminating pregnancy with painless abortion were randomly divided into two groups: group A (n = 65), group C (n = 66) and group C (n = 66). The patients were treated with misoprostol tablets (0.4mg) for 30 days and 6090 min before operation.The degree of cervical relaxation, the time of operation, the amount of bleeding before and during operation, the uterine contraction after operation, the load induced by propofol, the total amount of propofol and the adverse reactions were observed.Results there was no significant difference in the cervical relaxation rate between the two groups (P 0.05), but the cervical relaxation rate in group B was significantly higher than that in group A (P 0.05). The operative time of group B was significantly shorter than that of group A (P 0.05). The amount of preoperative bleeding in group B was similar to that in group A (P 0.05).The preoperative bleeding volume in group B was significantly lower than that in group C (P 0.05), the intraoperative bleeding volume in group B was significantly lower than that in group A (P 0.05), the excellent and good rate of uterine contraction in group B was higher than that in group C (P 0.05), the induced load of propofol in group B and the total dose of propofol in group B (group C) was significantly lower than that in group C (P 0.05).The incidence of adverse reactions was compared.The difference was not statistically significant (P 0.05).Conclusion: the application of misoprostol at 60 min before operation is more effective and safe than that of 30 ~ 90 min before operation, and it can reduce the dosage of propofol.
【作者单位】：临海市第一人民医院妇产科;
【分类号】：R169.42

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