新型毒品滥用者生活质量及色氨酸对其短期干预效果评价

发布时间：2018-04-27 21:50

本文选题：新型毒品滥用 + 生活质量　；参考：《华中科技大学》2013年硕士论文

【摘要】：目的：（1）了解武汉地区新型毒品滥用情况及滥用者身心和睡眠状况；（2）探索色氨酸对新型毒品滥用者睡眠和身心症状的治疗效果。方法：采用自制的基本情况调查表、症状自评量表（SCL-90）和阿森斯失眠量表（AIS）对武汉市公安局强制隔离戒毒所2012年4月-2012年11月收治的新型毒品滥用者进行调查，并从中筛选出80名受试对象随机分配到试验组和对照组，每组40人，试验组接受色氨酸（1000mg/day），对照组接受安慰剂，一共服用两周，在第一周末和第二周末分别再次进行调查。结果：（1）共调查323名新型毒品滥用者，其中男性和女性分别占79.6%（257/323）和20.4%（66/323）；年龄以21-30岁为主，占42.4%（137/323），平均为32.25±8.85岁；婚姻状况以未婚为主，占50.8%（164/323）；入所前职业以无业为主，，占45.8%（148/323）；文化程度以初中及以下为主，占67.2%（217/323）；使用毒品和使用方式分别以麻谷和烫吸为主，占67.2%（217/323）和74.9%（242/323）；吸毒年限以1-5年为主，占63.8%（206/323）；第一次使用毒品原因以好奇为主，占58.5%（189/323）；使用毒品场所以私人场所为主，占45.5%（147/323），且主要为群体使用，占58.2%（188/323）。（2）新型毒品滥用者与一般人群SCL-90各因子均分的差异均有统计学意义（P0.05），除人际关系得分低于一般人群，其余因子得分均高于一般人群。新型毒品滥用者中有睡眠问题者占69%（223/323），失眠者占44.5%（144/323）。苯丙胺类滥用者与K粉滥用者在人际关系、偏执、精神病性之间的差异无统计学意义（P0.05），而SCL-90其余的因子和睡眠之间的差异均有统计学意义（P0.05）。（3）试验组和对照组在治疗依从性和所有的基线资料上没有差异（P0.05）。两组间在阿森斯睡眠量表的分值上有差异（P0.05），且试验组分值下降较对照组明显，但二者在症状自评量表方面却没有差异（P0.05），包括所有的维度和总分。整个研究过程中没有出现严重的负面事件，且两组间出现负面事件的频率没有差异（P0.05）。结论：（1）武汉地区新型毒品滥用者身心和睡眠质量较差，相关部门应该采取有针对性的措施，提高新型毒品患者身心健康状况。（2）色氨酸可以短期内缓解新型毒品滥用者的睡眠症状，但不能缓解其身心症状。
[Abstract]:Objective to explore the therapeutic effect of tryptophan on sleep and psychosomatic symptoms of new drug abusers in Wuhan. Methods: the self-made basic information questionnaire, symptom Checklist 90 (SCL-90) and AIS (AIS) were used to investigate the new drug abusers treated in the compulsory isolation drug treatment center of Wuhan Public Security Bureau from April 2012 to November 2012. 80 subjects were randomly assigned to the experimental group and the control group, 40 in each group. The experimental group received 1000 mg / d tryptophan and the control group received a placebo for two weeks. The study was conducted again at the first weekend and the second weekend. Results: (1) A total of 323 new drug abusers were investigated, of whom 79.6% were male and 79.6% 323%, and 20.466% 323%; the age was mainly 21-30 years old, accounting for 42.47% 32330 years, with an average of 32.25 卤8.85 years old; marriage status was mainly unmarried, accounting for 50.816 / 323%; and before entering the university, the occupation was dominated by non-employment. 45.8% / 323%; the education level is mainly junior high school and below, accounting for 67.2% of 323%; the use of drugs and the way of using drugs are mainly hemp valley and hot suction, respectively, 67.22% 323) and 74.9% 242 / 323; the number of years of drug use is 1-5 years, accounting for 63.8% 206323%; the first use of drugs is mainly because of curiosity. 58.5% 1899 / 323; drug use was mainly in private places, accounting for 45.5% of 323%, and was mainly used in groups, accounting for 58.2% of the total. (2) there were significant differences in the average scores of SCL-90 between the new drug abusers and the general population (P 0.05). The scores of other factors were higher than those of the general population, except the interpersonal relationship score was lower than that of the general population. Among the new drug abusers, sleep problems accounted for 69 / 223 / 323, and insomnia for 44. 5 / 324 / 323. There was no significant difference in interpersonal relationship, paranoid ideation and psychosis between amphetamine-type abusers and K-substance abusers, but the differences between other factors of SCL-90 and sleep were statistically significant (P 0.05). There was no difference in treatment compliance and all baseline data between the trial group and the control group (P 0.05). There were significant differences in Ascension sleep scale scores between the two groups, and the scores of the test group were significantly lower than those of the control group, but there was no difference in the symptom Checklist between the two groups, including all dimensions and total scores. There were no serious negative events in the whole study, and there was no difference in the frequency of negative events between the two groups (P 0.05). Conclusion (1) the mental, physical and sleep quality of new-type drug abusers in Wuhan area is poor. Relevant departments should take targeted measures to improve the physical and mental health of new-type drug abusers. Tryptophan can relieve sleep symptoms of new drug abusers in the short term, but not physical and mental symptoms.
【学位授予单位】：华中科技大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R163

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