低矿物质饮水对兔血清矿物质水平和血液酸碱度的影响

发布时间：2018-04-30 22:32

本文选题：低矿物质饮水 + 人工矿物质水　；参考：《第三军医大学学报》2017年11期

【摘要】：目的观察长期饮用低矿物质饮水后对机体矿物质水平及酸碱平衡的影响。方法受试饮水分别为自来水[A,溶解性总固体(total dissolved solid,TDS)为229.0 mg/L]、低矿水一(B,TDS:87.2 mg/L)、低矿水二(C,TDS:10.9 mg/L,在纯净水中人工添加氯化钾和硫酸镁)、低矿水三(D,TDS:1.2 mg/L,纯净水)。健康雄性新西兰兔48只,采用随机数字表法分为4组,每组12只,分别自由饮用上述4种水12个月,期间观察体质量、24 h饮水量。第12个月末取静脉血采用以电极法为原理的全自动生化分析仪检测血清中钠、钾、钙、镁含量,取动脉血用血气分析测试片于便携式血气分析仪上检测酸碱度(pH)、二氧化碳总量(TCO_2)、实际碳酸氢盐(AB-HCO-3)、剩余碱(BE)、二氧化碳分压[p(CO_2)]、氧分压[p(O_2)]、氧饱和度(SO_2)。结果与A组相比,B、C、D组血钾均有升高趋势,其中C组的增高差异有统计学意义(P0.05)。同时,与A组相比,C组和B组的pH值显著性降低(P0.05)。3个低矿水组(B、C、D)的代谢性酸碱平衡指标TCO_2、AB-HCO_3~-和BE都出现降低趋势,其中C组和B组的降低差异有统计学意义(P0.05、P0.01),且低于同种动物正常范围下限,4组动物中C组(人工矿物质水)水平最低。结论长期饮用低矿物质饮水可能会升高血钾水平,减少机体代谢性碱储备,降低血液pH值。对低矿物质饮水进行人工矿化时应该十分慎重,避免引发新的健康风险。
[Abstract]:Objective to observe the effect of drinking low-mineral water on mineral level and acid-base balance. Methods drinking water was tap water (A, total dissolved solidTDS = 229.0 mg/L), low mineral water (TDs: 87.2 mg / L), low mineral water (TDS: 10.9 mg / L), potassium chloride and magnesium sulfate added artificially in purified water, low mineral water: TDs: 1.2 mg / L, pure water. 48 healthy male New Zealand rabbits were randomly divided into 4 groups (12 rabbits in each group). At the end of the 12th month, venous blood was collected to detect the contents of sodium, potassium, calcium and magnesium in serum by an automatic biochemical analyzer based on electrode method. Arterial blood samples were used for the determination of pH value (pH), total carbon dioxide (CO _ 2), AB-HCO _ (-3), residual alkaloid, partial pressure of CO _ (2), partial pressure of oxygen (P _ (P) O _ (2), O _ (2) and oxygen saturation (O _ (2) on a portable blood gas analyzer. Results compared with group A, the level of serum potassium in group C was higher than that in group A, and the increase of serum potassium in group C was significantly higher than that in group C (P 0.05). At the same time, compared with group A, pH value of group C and group B was significantly lower than that of group A. The metabolic acid-base balance index TCO2AB-HCO3- and be of three low mineral water groups were decreased. The difference between group C and group B was statistically significant, and the level of artificial mineral water in group C was lower than that in group C (artificial mineral water). Conclusion drinking low mineral water for a long time may increase serum potassium level, decrease metabolic alkali reserve and decrease blood pH value. The artificial mineralization of low-mineral water should be careful to avoid new health risks.
【作者单位】：第三军医大学军事预防医学院军队环境卫生学教研室;
【基金】：国家自然科学基金重点项目(81230064);国家自然科学基金青年科学基金(81001234) 重庆市卫生局医学科研项目(2012-2-447)~~
【分类号】：R123

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