饮用淡化海水对大鼠血清中转氨酶的影响

发布时间：2018-05-14 13:01

本文选题：淡化海水 + 丙氨酸氨基转移酶　；参考：《环境与健康杂志》2015年05期

【摘要】：目的研究饮用淡化海水对大鼠血清中转氨酶的影响。方法将120只健康清洁级Wistar大鼠按体重随机分为淡化海水[仅硼含量(1.3 mg/L)超过GB 5749—2006《生活饮用水卫生标准》]组和市政自来水组,每组30只,雌雄各半。采用自由饮水方式进行染毒,连续染毒1年。分别于染毒前和第90、180天、1年时,采集血液,通过全自动生化分析仪测定天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)活力。结果与市政自来水组比较,仅饮用淡化海水1年的雌性大鼠及饮用淡化海水180 d的雄性大鼠血清ALT、AST活力均较低,仅饮用淡化海水90 d的雌性大鼠血清AST/ALT值较高,差异有统计学意义(P0.05);而饮用淡化海水雄性大鼠血清的AST/ALT值无明显变化。结论饮用淡化海水不会引起受试大鼠肝实质损伤。
[Abstract]:Objective to study the effect of drinking desalination seawater on serum aminotransferase in rats. Methods 120 healthy and clean grade Wistar rats were randomly divided into desalinated seawater (1.3 mg / L boron content) and municipal tap water group (30 rats in each group). Use free drinking water for 1 year. Blood samples were collected before and 90180 days after exposure, and the activities of aspartate aminotransferase (AST) and alanine aminotransferase (alt) were measured by automatic biochemical analyzer. Results compared with municipal tap water group, the serum alt AST activity of female rats drinking desalinated seawater for one year and male rats drinking desalinated seawater for 180 days was lower, and the serum AST/ALT level of female rats drinking desalinated seawater for 90 days was higher. The difference was statistically significant (P 0.05), but there was no significant change in serum AST/ALT value of male rats drinking desalinated seawater. Conclusion drinking desalinated seawater does not cause liver parenchyma injury in rats.
【作者单位】：中国疾病预防控制中心环境与健康相关产品安全所环境毒理室;
【基金】：国家海洋局海洋公益性行业科研专项(201305039-6)
【分类号】：R123

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