二甲基甲酰胺暴露性肝损伤的Meta分析

发布时间：2018-05-21 13:28

本文选题：DMF暴露 + Meta分析　；参考：《浙江大学》2012年硕士论文

【摘要】：目的探讨二甲基甲酰胺暴露性肝损伤发生的主要危险因素,为预防决策提供科学依据。方法应用Meta分析方法对二甲基甲酰胺暴露性肝损伤的现况研究进行定量综合分析,以合适的关键词检索符合纳入与排除标准的文献(1998年至2011年),提取所需的数据和有关资料。应用Review Manager5软件对各研究结果进行一致性检验和采用相应的数学模型进行数据再处理,包括异质性检验、效应值合并、敏感性分析和偏倚估计等。结果12个现况研究异质性检验显示纳入的研究间存在明显的异质性。效应值合并分析显示DMF暴露对肝损伤(OR,6.31；95%CI,3.10-12.85)有显著的作用。以敏感性分析的结果显示在自觉症状亚组分析和肝功能检测指标亚组分析差异有统计学意义,具有重要的临床效应。漏斗图分析表明没有明显的发表偏倚。结论以上OR和95%CI有力地证明了DMF暴露对肝损伤有统计学意义的显著作用,也有重要的临床效应。探讨DMF暴露对人体的健康作用期待更多的研究。
[Abstract]:Objective to explore the main risk factors of liver injury induced by dimethylformamide and to provide scientific basis for prevention and decision-making. Methods Meta analysis was used to analyze the current situation of exposure liver injury induced by dimethylformamide. The relevant data and relevant data were extracted from the relevant documents (1998 to 2011) by using suitable keywords to search the literature that met the inclusion and exclusion criteria. The Review Manager5 software was used to verify the consistency of the results and the corresponding mathematical models were used to reprocess the data, including heterogeneity test, effect value combination, sensitivity analysis and bias estimation. Results the heterogeneity test of 12 status studies showed significant heterogeneity among the included studies. The combined effect value analysis showed that DMF exposure had a significant effect on the liver injury. The results of sensitivity analysis showed that there were significant differences between subgroup analysis of conscious symptoms and subgroup analysis of liver function test, which had important clinical effect. Funnel analysis showed no apparent publication bias. Conclusion the above OR and 95%CI prove that DMF exposure has significant effect on liver injury and has important clinical effect. More studies are expected to explore the effects of DMF exposure on human health.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R131

【参考文献】