2000-2013年玉林市检出脊髓灰质炎疫苗病毒的急性驰缓性麻痹病例流行病学分析

发布时间：2018-05-22 11:08

  本文选题：急性驰缓性麻痹 + 脊髓灰质炎疫苗病毒　； 参考：《现代预防医学》2015年09期

【摘要】：目的分析脊髓灰质炎(脊灰)病毒(PV)的急性驰缓性麻痹(AFP)病例流行病学特征,为维持无脊髓灰质炎状态提供科学依据。方法采用描述性流行病学方法对玉林市2000-2013年检出的PV阳性AFP病例进行流行病学分析。结果玉林市2000-2013年共检测了451例急性驰缓性麻痹病例的粪便标本,检出PV13株,检出率2.88%,型内特征鉴定有1株为疫苗变异PV,经VP1基因核苷酸序列测定达到VDPV的分类标准。分离到的PV以Ⅱ型为主,AFP病例散在发生,无聚集性。未全程免疫儿童全程免疫儿童,年龄以≤1岁儿童为主(92.31%)。服苗1月内出现麻痹占46.15%(6/13),麻痹伴发热占61.54%,60 d后随访仍残留麻痹病例高达23.08%,以Ⅱ型疫苗株为主。结论玉林市2000-2013年未发现由脊灰野病毒引起的病例。在无脊灰证实阶段,存在着疫苗衍生病毒(VDPV)和发生VDPV循环(c VDPVs)的可能,保持AFP病例监测的敏感性,加强对脊灰疫苗衍生病毒的监测及研究,具有重要的现实意义。
[Abstract]:Objective to analyze the epidemiological characteristics of acute flaccid paralysis (AFP) of poliovirus (PVV) in order to provide scientific basis for maintaining poliomyelitis free state. Methods Epidemiological analysis of PV positive AFP cases from 2000 to 2013 was carried out in Yulin. Results A total of 451 fecal specimens of patients with acute flaccid paralysis were detected in Yulin city from 2000 to 2013. The detection rate of PV13 strain was 2.88. One strain was identified as vaccine variant by intratype characterization. The nucleotide sequence analysis of VP1 gene reached the classification standard of VDPV. The PV isolated was mainly type 鈪，

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