DHA藻油软胶囊改善小鼠记忆功能的研究

发布时间：2018-06-04 12:55

本文选题：DHA + 记忆　；参考：《卫生研究》2015年01期

【摘要】：目的探讨DHA藻油软胶囊辅助改善记忆功能的作用。方法将144只昆明种小鼠分为3组,分别用于跳台实验、避暗实验和水迷宫实验。每项实验取48只,随机分为4组,每组12只。根据DHA藻油软胶囊人体推荐剂量600 mg/d,本实验按成人体重60 kg计,3个剂量组分别为50、100和300 mg/kg BW(相当于人拟用剂量的5、10、30倍),经口灌胃量为10 ml/kg BW,对照组给予等量食用植物油,每日一次,连续灌胃30 d。于末次灌胃后次日,分别进行跳台实验、避暗实验和水迷宫实验。结果 DHA藻油软胶囊制剂低、中、高3个剂量组小鼠跳台试验潜伏期延长、错误次数减少、跳下平台动物百分率降低;避暗潜伏期延长、错误次数减少、进入暗室动物百分率降低(P0.05)。水迷宫试验中,高剂量组在到达终点时间、到达终点前错误次数及达到终点的动物百分率与对照组差异有统计学意义(P0.05)。结论DHA藻油软胶囊具有辅助改善小鼠记忆的功能。
[Abstract]:Objective to investigate the effect of DHA algal oil soft capsule on improving memory function. Methods 144 Kunming mice were divided into 3 groups, which were used in platform diving experiment, dark experiment and water maze test. 48 rats were randomly divided into 4 groups, each group was 12. According to the recommended dose of 600 mg/d for DHA algal oil soft capsules, the experiment was 60 kg for adult and 3. The dose group was 50100 and 300 mg/kg BW (equivalent to the 5,10,30 times of the human dose), the oral administration of the stomach was 10 ml/kg BW, the control group was given the same amount of edible vegetable oil, once a day and 30 d. to the last day after the last irrigation, and the experiment of the platform, the dark experiment and the water maze test were carried out respectively. The results of DHA algal oil soft capsule preparation were low, middle and high. The incubation period of the 3 dose groups was prolonged, the number of errors decreased, the percentage of the animals in the lower platform decreased, the dark latency was prolonged, the number of errors decreased, and the percentage of the animals in the darkroom decreased (P0.05). In the water maze test, the number of errors and the percentage of animals reached the end of the end to the end of the end of the end of the end of the end of the end of the water maze test. The difference between the control group was statistically significant (P0.05). Conclusion DHA algal oil soft capsule has the function of assisting in improving the memory of mice.
【作者单位】：中国疾病预防控制中心营养与健康所卫生部微量元素营养重点实验室;
【基金】：中国营养学会营养科研基金——帝斯曼专项科研基金
【分类号】：R151

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