薛荔籽果胶对高脂膳食去势大鼠脂质代谢及盲肠内环境的影响

发布时间：2018-06-05 22:30

本文选题：薛荔籽果胶 + 高脂膳食　；参考：《食品科学》2015年15期

【摘要】：目的:研究薛荔籽果胶对高脂膳食去势大鼠脂质代谢及盲肠内环境的影响。方法:将40只健康雌性Sprague-Dawley(SD)大鼠随机分为5组,其中1组作为空白对照进行卵巢伪切除手术(Sham组),另外4组进行双侧卵巢切除手术(OVX组),1周后分为模型对照组和饲喂5%、10%、15%薛荔籽果胶低、中、高剂量组。喂养4周后解剖测定大鼠血脂和肝脂含量、肝脏组织形态,以及盲肠内容物含水率和短链脂肪酸(shortchain fatty acids,SCFAs)含量等指标。结果:模型对照组大鼠的血脂以及肝脏质量、肝脏脂肪含量、每克肝脏中胆固醇、甘油三酯含量显著高于双侧卵巢伪切除组(P0.05)。薛荔籽果胶对双侧卵巢切除大鼠的血脂浓度几乎没有影响,而肝脏质量有升高趋势,但无显著性差异;同时能显著升高盲肠壁湿质量、盲肠壁表面积、盲肠组织湿质量和盲肠内容物湿质量(P0.05);也能升高盲肠内容物中各SCFAs和总SCFAs含量,且具有明显的剂量关系。结论:薛荔籽果胶对高脂膳食引起高脂血症去势大鼠的血脂、肝脂没有降低效果,反而升高了肝脂水平,但在肠道方面,能改善高脂膳食去势大鼠肠道健康。
[Abstract]:Aim: to study the effects of Xue Lizhuang pectin on lipid metabolism and caecum environment in ovariectomized rats. Methods: forty healthy female Sprague-Dawley SD rats were randomly divided into 5 groups. One group was used as a blank control group for sham group, the other four groups were divided into model control group and medium and high dose group after bilateral ovariectomy. After feeding for 4 weeks, serum lipids and liver lipid contents, liver tissue morphology, water content of caecum contents and short chain fatty acid shortchain fatty acidsof SCF Ass were measured. Results: the serum lipids, liver weight, liver fat content, cholesterol and triglyceride content per gram of liver in the model control group were significantly higher than those in the bilateral pseudo-ovariectomized group (P 0.05). Xue Lizi Pectin had little effect on blood lipid concentration in bilateral ovariectomized rats, but the liver quality increased, but there was no significant difference, at the same time, the wet mass of cecum wall and the surface area of cecum wall were significantly increased. The wet mass of cecum tissue and the wet mass of cecum contents (P0.05) could also increase the contents of SCFAs and total SCFAs in cecum contents in a dose-dependent manner. Conclusion: Xue Lizi Pectin can improve the intestinal health of ovariectomized rats induced by high fat diet, but not decrease the liver fat, but increase the level of liver fat, but improve the intestinal health of the ovariectomized rats with high fat diet.
【作者单位】：西南大学食品科学学院;
【基金】：教育部留学回国人员科研启动基金项目(教外司留[2010]1174)
【分类号】：R151

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