评估多氯联苯吸入所导致的健康风险:解决不确定性的研究需求

发布时间：2018-06-13 09:57

  本文选题：PCBs + 氯联苯　； 参考：《环境与职业医学》2015年06期

【摘要】：[背景]在一些建筑物内,多氯联苯(PCBs)的室内空气浓度要比背景值高出一个甚至更多的数量级。为此,人们试图评估吸入PCBs所造成的潜在健康风险。但是由于来源、暴露和暴露-反应的特征描述以及评估中存在着不确定性,这些尝试受到了阻碍。[目的]简要介绍室内空气中PCBs的一些常见来源,并估计特定年龄组的吸入暴露对总PCBs暴露的贡献量。随后,确定需要进行重点研究的领域,以提高对PCBs吸入暴露和暴露反应的评估水平。[讨论]虽然美国在1979年就开始禁止生产PCBs,但在此之前建造的许多建筑中仍含有潜在的污染来源,造成室内空气PCBs污染。在一些室内条件下和一些年龄组中,吸入暴露对PCBs总暴露的贡献可能大于其他任何暴露途径。PCBs暴露与人体健康效应相关,但针对吸入途径的数据仍然很少。为了进行暴露-反应评估,在今后研究PCBs吸入的健康效应时要仔细考虑研究设计的一些方面,包括描述PCBs混合暴露的特征,这一点十分重要。[结论]在某些情况下,PCBs的吸入暴露对PCBs总暴露的贡献量可能比以前认为的更多。新的流行病学和毒理学研究致力于解决PCBs吸入对健康的潜在影响,可能有助于确定暴露-反应关系和进行风险评估。
[Abstract]:[background] in some buildings, PCBs) indoor air concentrations are one or more orders of magnitude higher than the background values. To this end, attempts are made to assess the potential health risks associated with inhalation of PCBs. However, these attempts were hampered by uncertainties in source, characterization of exposure and exposure-response and evaluation. [objective] to introduce some common sources of PCBs in indoor air, and to estimate the contribution of inhaled exposure to total PCBs in specific age groups. Areas that need to be studied to improve assessment of PCBs exposure and exposure response are then identified. Although the production of PCBswas banned in the United States in 1979, many buildings built prior to that still contained potential sources of pollution, resulting in indoor air PCBs pollution. In some indoor conditions and in some age groups, the contribution of inhaled exposure to total exposure to PCBs may be greater than that of any other exposure pathway. PCBs exposure is associated with human health effects, but the data on inhalation pathways are still scarce. In order to assess exposure-response, it is important to consider some aspects of the design in future studies of the health effects of PCBs inhalation, including describing the characteristics of mixed exposure to PCBs, which is important at 01:10. [conclusion] in some cases, inhalation exposure of PCBs may contribute more to total exposure to PCBs than previously thought. New epidemiological and toxicological studies focus on addressing the potential health effects of PCBs inhalation, which may help determine exposure-response relationships and risk assessment.
【分类号】：R114

【相似文献】

相关期刊论文 前4条

1 李俊岭;张东平;余应新;韩姝媛;吴明红;盛国英;傅家谟;;动物性食品中PCBs的生物有效性及人体日暴露评估[J];中国环境科学;2011年06期

2 鲍家启 ,翁甘霖;接触多氯联苯(PCBs)工人的肾癌[J];劳动医学;1991年02期

3 Hirokadzu Kodama;Hideo Ota;袁宝珊;;多氯联苯(PCBs)由母体转移给婴儿的研究[J];兰州医学院学报;1981年01期

4 ;[J];;年期

相关重要报纸文章 前1条

1 南方周末记者 吕明合;资阳病人[N];南方周末;2011年

，

本文编号：2013634