医学放射工作人员血清免疫相关细胞因子变化研究

发布时间：2018-06-13 10:17

本文选题：低剂量 + 电离辐射　；参考：《中国职业医学》2017年02期

【摘要】：目的了解接触低剂量电离辐射医学放射工作人员机体免疫相关细胞因子的变化情况。方法采用典型抽样法,选取广东省7家三级甲等医院244名医学放射工作人员为研究对象,其中诊断放射学组、核医学组、放射治疗组、介入放射学组分别有61、51、74和58人。另选工作中不接触电离辐射的51名行政人员为对照组。采用热释光剂量仪对接触组人员进行为期1年的个人剂量监测。采用酶联免疫吸附实验检测各组人员血清中γ干扰素(IFN-γ)、白细胞介素10(IL-10)和转化生长因子β1(TGF-β1)表达水平。结果医学放射工作人员的最大人均年有效剂量为0.41 mSv/a,低于职业接触限值20.00 mSv/a。核医学组工作人员人均年有效剂量分别高于诊断放射学组、放射治疗组和介入放射学组(P0.01)。男性工作人员中,诊断放射学组、放射治疗组和介入放射学组人员血清IL-10表达水平均低于对照组(P0.05);放射治疗组人员的IL-10表达水平分别低于核医学组和介入放射学组(P0.05);放射治疗组人员的IFN-γ/IL-10比值分别高于诊断放射学组、核医学组、介入放射学组和对照组(P0.05)。将医学放射工作人员按人均年有效剂量分为低、中、高3个剂量组(0.03~、0.06~和0.15 mSv/a),该3组男性工作人员的IL-10表达水平均低于对照组男性工作人员(P0.05)。结论长期低剂量电离辐射可能对男性工作人员IL-10介导的体液免疫产生一定的抑制作用。
[Abstract]:Objective to investigate the changes of immune related cytokines in medical radiation workers exposed to low dose ionizing radiation. Methods A total of 244 medical radiation workers from 7 Grade 3A hospitals in Guangdong Province were selected as the study subjects, including diagnostic radiology group, nuclear medicine group, radiotherapy group and interventional radiology group. Another 51 administrative staff members who were not exposed to ionizing radiation were selected as control group. The personnel of contact group were monitored with thermoluminescence dose meter for one year. The levels of IFN- 纬 (IL-10) and TGF- 尾 _ 1 (TGF- 尾 _ 1) of IFN- 纬 and TGF- 尾 _ 1 were measured by enzyme-linked immunosorbent assay (Elisa). Results the maximum per capita annual effective dose of medical radiation workers was 0.41 mSv / a, which was lower than the occupational exposure limit of 20.00 mSv-a. The average annual effective dose of nuclear medicine workers was higher than that of diagnostic radiology group, radiotherapy group and interventional radiology group (P 0.01). Among the male staff, the Diagnostic Radiology Unit, The level of serum IL-10 expression in radiotherapy group and interventional radiology group was lower than that in control group (P 0.05), the level of IL-10 expression in radiation group was lower than that in nuclear medicine group and interventional radiology group, and the ratio of IFN- 纬 / IL-10 in radiotherapy group was lower than that in control group. Higher than diagnostic radiology, Nuclear medicine group, interventional radiology group and control group (P 0.05). According to the annual effective dose per person, the medical radiation workers were divided into three groups: middle and high dose groups. The levels of IL-10 expression in the three groups were lower than those in the control group (P 0.05), and the levels of IL-10 expression in the three groups were lower than those in the control group (0.06 ~ 0.15 mSv / a). Conclusion long-term low-dose ionizing radiation may inhibit humoral immunity mediated by IL-10 in male workers.
【作者单位】：南方医科大学;广东省职业病防治院广东省职业病防治重点实验室;广东省妇幼保健院;
【基金】：卫生行业科研专项(201002009) 广东省医学科学技术研究基金(B2014012)
【分类号】：R14

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