有害结局通路指南及毒性测试应用分析

发布时间：2018-06-15 07:03

本文选题：有害结局通路 + 替代方法　；参考：《日用化学工业》2016年08期

【摘要】：综述了在21世纪毒性测试愿景与策略倡议下,以及现代科技发展和法规监管体系变革的背景下,有害结局通路(AOP)的提出和发展。重点介绍了AOP的概念和指南,AOP的基本组成、构建条件和信息共享,AOP的网络和评估;讨论了AOP在皮肤致敏和鱼类早期发育2个毒性终点的开发和应用情况,及其作为自上而下和从中间开始的2种AOP开发策略的实例;最后提出了AOP以现代科技发展为动力、毒性预测现代化为基础、推动法规监管模式变革为目标的发展策略。AOP指南也为替代动物测试方法的开发和检测技术创新提供了难得的机遇。
[Abstract]:Under the initiative of vision and strategy of toxicity testing in the 21st century and the background of the development of modern science and technology and the reform of regulatory system, the harmful outcome pathway (AOPs) was proposed and developed. The concept of AOP and the basic composition of AOP, the construction conditions and the network and evaluation of AOP for information sharing are introduced, and the development and application of AOP in skin sensitization and fish early development are discussed. As an example of two AOP development strategies from top to bottom and from the middle, it is proposed that AOP is based on the development of modern science and technology and the modernization of toxicity prediction. AOP guidelines also provide a rare opportunity for the development of alternative animal testing methods and the innovation of testing techniques.
【作者单位】：国际人道对待动物协会;广东出入境检验检疫局技术中心;广州市华代生物科技有限公司;
【基金】：广东省科技计划资助项目(2015A030402005)
【分类号】：R114

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