四种饮用水对小鼠非特异性免疫的影响

发布时间：2018-06-18 17:57

本文选题：饮用水 + 免疫器官　；参考：《环境与健康杂志》2015年07期

【摘要】：目的探讨不同饮用水对小鼠非特异性免疫的影响。方法将160只3周龄清洁级ICR小鼠随机分为4组,分别为自来水组、纯净水组、矿泉水组、净化水组,每组40只,雌雄各半。各组小鼠自由饮水摄食60 d。选取80只小鼠进行碳廓清实验,称重,测定胸腺、脾脏重量并计算脏器系数;另选80只清洁级ICR小鼠进行小鼠腹腔巨噬细胞吞噬鸡红细胞实验。结果各组小鼠的体重、脾脏系数、胸腺系数、廓清指数及吞噬指数间比较,差异均无统计学意义(P0.05);但与其他3组比较,净化水组胸腺系数和廓清指数有上升趋势。与自来水组、纯净水组比较,净化水组雄性小鼠的腹腔巨噬细胞吞噬百分率和吞噬指数升高,差异均有统计学意义(P0.05);净化水组雌性小鼠的腹腔巨噬细胞吞噬百分率和吞噬指数高于自来水组、纯净水组及矿泉水组,差异均有统计学意义(P0.05)。结论与自来水、纯净水及矿泉水相比,长期饮用净化水在一定程度上可提高小鼠非特异性免疫力。
[Abstract]:Objective to investigate the effect of drinking water on non-specific immunity in mice. Methods 160 3-week-old clean ICR mice were randomly divided into four groups: tap water group, purified water group, mineral water group and purified water group. The mice in each group were fed freely for 60 days. Eighty mice were selected for carbon clearance test, weighing, thymus and spleen weight and organ coefficient calculation, and 80 ICR mice of clean grade were selected for phagocytosis of chicken red blood cells by peritoneal macrophages. Results there was no significant difference in body weight, spleen coefficient, thymus coefficient, clearance index and phagocytosis index between the three groups, but the thymus coefficient and clearance index of purified water group had an increasing trend compared with the other three groups. Compared with tap water group and purified water group, the phagocytic percentage and phagocytic index of peritoneal macrophage in purified water group were increased. The phagocytic percentage and phagocytic index of peritoneal macrophages in purified water group were higher than those in tap water group, and the difference was statistically significant in pure water group and mineral water group. Conclusion compared with tap water, purified water and mineral water, drinking purified water for a long time can improve the nonspecific immunity of mice to some extent.
【作者单位】：福建医科大学卫生检验与检疫学系;福建晋江市内坑卫生院;福建省肿瘤医院肿瘤免疫学研究室;福建省润和矿泉水有限公司;
【基金】：福建省科技计划重大项目(2012Y4004)
【分类号】：R123

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