广州市儿童维生素D水平及其与甲状旁腺素的关系

发布时间：2018-06-19 14:48

本文选题：维生素D + 甲状旁腺素　；参考：《中国学校卫生》2017年03期

【摘要】：目的了解广州市儿童维生素D水平及其与甲状旁腺素(PTH)的关系,为减少儿童维生素D缺乏性疾病的发生和改善儿童骨骼健康提供科学依据。方法采用横断面研究,对2015年广州市某妇幼保健院健康体检的976名儿童进行体格检查,采集空腹静脉血,用化学发光法检测血清25-羟维生素D[25(OH)D]和甲状滂腺素(PTH)。结果儿童血清25(OH)D平均水平为(90.67±36.55)nmol/L,其中男童为(90.14±34.89)nmol/L,女童为(91.33±38.58)nmol/L,差异无统计学意义(P0.05)。维生素D缺乏率及不足率分别为11.37%和25.31%,性别间差异无统计学意义(P0.05)。不同年龄儿童血清25(OH)D水平差异有统计学意义(F=55.547,P0.05),血清25(OH)D水平随年龄增长呈下降趋势。不同年龄儿童维生素D营养状况差异有统计学意义(χ2=87.352,P0.05),维生素D缺乏率及不足率随年龄增长而升高(χ2趋势=68.909,P0.05)。儿童血清PTH平均水平为(2.38±1.29)pmol/L,维生素D缺乏及不足儿童血清PTH水平均高于维生素D充足儿童,差异有统计学意义(F=10.427,P0.05)。血清25(OH)D水平与PTH呈负相关(r=-0.149,P=0.000)。结论广州市0~16岁儿童维生素D缺乏率及不足率较高,年长儿童维生素D营养状况较年幼儿童差,血清25(OH)D与PTH水平呈负相关。应采取合理措施改善儿童维生素D的营养状况。
[Abstract]:Objective to investigate the level of vitamin D and its relationship with PTH in children in Guangzhou, so as to provide scientific basis for reducing the incidence of vitamin D deficiency in children and improving children's bone health. Methods A cross-sectional study was carried out on 976 children who underwent physical examination in a maternal and child health care hospital in Guangzhou in 2015. Fasting venous blood samples were collected, and serum 25-hydroxyvitamin D (25-OHH) and pang glandin (PTH) were detected by chemiluminescence. Results the average serum level of 25 OHH / L in children was 90.67 卤36.55 nmol / L, 90.14 卤34.89 nmol / L for boys and 91.33 卤38.58 nmol / L for girls, respectively. There was no significant difference between them (P 0.05). The rates of vitamin D deficiency and deficiency were 11.37% and 25.31%, respectively. There were significant differences in serum 25 OHH D levels among children of different ages (P 0.05), and the serum 25 OHH D levels decreased with the increase of age. There were significant differences in vitamin D nutritional status among children of different ages (蠂 ~ 2 = 87.352P 0.05). The rate of vitamin D deficiency and deficiency increased with the increase of age (蠂 ~ 2 trend: 68.909 / P 0.05). The average level of serum PTH in children was 2.38 卤1.29 mmol / L, and the levels of serum PTH in children with vitamin D deficiency and deficiency were higher than those in children with adequate vitamin D, and the difference was statistically significant (P 0.05). There was a negative correlation between serum 25 OHH D and PTH. Conclusion Vitamin D deficiency rate and deficiency rate were higher in 16 year old children in Guangzhou, vitamin D nutritional status of older children was worse than that of young children, and serum 25 OHH D was negatively correlated with PTH level. Reasonable measures should be taken to improve the nutritional status of vitamin D in children.
【作者单位】：广东药科大学公共卫生学院;广东省妇幼保健院放射科;
【基金】：地方高校国家级大学生创新创业训练计划项目(201610573001)
【分类号】：R153.2

【相似文献】