黑木耳多糖降血脂作用的小鼠实验分析

发布时间：2018-06-19 15:49

本文选题：黑木耳多糖 + 高血脂症　；参考：《食品研究与开发》2017年23期

【摘要】：采用不同剂量的两种黑木耳酸性多糖(Auricularia Polysaccharide,AP)对高脂模型小鼠进行灌胃,研究黑木耳多糖对高脂模型小鼠脂肪指数及相关酶类影响并初步探究黑木耳酸性多糖的降血脂作用。结果表明,两种黑木耳多糖均可增加小鼠粪便中的胆酸盐含量、卵磷脂胆固醇酰基转移酶(lecithin-cholesterolacyltransferase,LCAT)含量(p0.05)以及激素敏感性脂肪酶(hormone-sensitive triglayceride lipase,HSL)含量(p0.05);降低小鼠脂肪指数、HMG-CoA还原酶(Hydroxy methylglutaryl coenzyme A reductase inhibitor,HMGR)含量以及胰岛素(insulin,INS)活性;且碱提除蛋白多糖组(JC组)的效果优于碱提不除蛋白组(J组)。说明两种黑木耳多糖可通过调节相关酶的活性,达到降血脂的效果,且JC组的效果更好。
[Abstract]:Two kinds of Auricularia Polysaccharide (Auricularia Polysaccharide) of different dosages were used to gavage the hyperlipidemia model mice. The effects of Auricularia Polysaccharide on fat index and related enzymes in hyperlipidemic mice were studied and the hypolipidemic effect of Auricularia Polysaccharide was preliminarily studied. The results showed that two kinds of Auricularia auricularia polysaccharides could increase the content of cholate in the feces of mice. The contents of lecithin-cholesterol acyltransferase (lecithin-cholesterol transferase) and hormone-sensitive triglayceride lipase (HSLs) of lecithin-cholesterolacyltransferase (lecithin-cholesteryl transferase) and hormone-sensitive triglayceride lipase (HSLs) were p0.05; the content of HMG-CoA reductase hydroxy methylglutaryl coenzyme A reductase inhibitor (HMGR) and the activity of insulin insulininine (ins) were decreased in mice. The effect of alkali extraction of proteoglycan group (JC group) was better than that of alkali extraction group (group J). The results showed that two kinds of Auricularia auricularia polysaccharides could reduce blood lipid by regulating the activity of related enzymes, and the effect of JC group was better than that of JC group.
【作者单位】：东北林业大学林学院;哈尔滨工业大学食品科学与工程学院;
【基金】：黑龙江省林业科学院2014年度科学试验研究实施计划(GA13B202)
【分类号】：R151

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