张家港市乙肝疫苗和乙肝免疫球蛋白阻断乙肝母婴传播效果评价

发布时间：2018-06-21 05:55

  本文选题：乙型肝炎病毒 + 垂直传播　； 参考：《现代预防医学》2017年02期

【摘要】：目的评价乙肝疫苗和乙肝免疫球蛋白联合免疫对乙肝病毒母婴传播的阻断效果。方法从张家港市设有产科的所有医院选取母亲为乙肝病毒表面抗原(HBs Ag)阳性且已接种乙肝疫苗和乙肝免疫球蛋白的婴幼儿512人,随访调查母亲乙肝病毒感染情况,分娩方式等,并检测婴幼儿血清中HBs Ag和乙肝病毒表面抗体(HBs Ab)水平。结果调查婴幼儿中,HBs Ag阳性率为1.76%,HBs Ab阳性率为87.11%。不同性别、不同分娩方式对婴幼儿乙肝感染率的影响差异无统计学意义。≤12月龄、12月龄~和≥24月龄的婴幼儿HBs Ab阳性率分别为100.00%、90.91%和84.62%。结论乙肝疫苗和乙肝免疫球蛋白阻断HBs Ag阳性母亲垂直传播乙肝病毒效果显著,婴幼儿体液免疫水平随月龄增加而逐步降低。
[Abstract]:Objective to evaluate the blocking effect of hepatitis B vaccine and hepatitis B immunoglobulin on mother-to-child transmission of hepatitis B virus. Methods A total of 512 infants were selected from all hospitals with obstetrics in Zhangjiagang city who were HBV surface antigen positive and vaccinated with hepatitis B vaccine and hepatitis B immunoglobulin, and their mothers were followed up to investigate the situation of hepatitis B virus infection and the way of delivery, etc. Serum HBs Ag and HBV surface antibody (HBs Abb) were detected. Results the positive rate of HBs Ag in infants was 1.76 and the positive rate of HBs Ab was 87.11. The positive rates of HBs Ab in infants 鈮，

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