太明清对扑热息痛致小鼠肝损伤的保护作用

发布时间：2018-06-24 16:05

本文选题：太明清 + 扑热息痛　；参考：《现代食品科技》2015年01期

【摘要】：本研究对韩国传统饮品太明清(TMC)对扑热息痛所致小鼠肝损伤的保护作用进行了研究,ICR小鼠连续14 d灌胃给予低(100 mg/kg)、中(250 mg/kg)、高(500 mg/kg)三个剂量的太明清及阳性药物水飞蓟素(100 mg/kg)后,腹腔注射扑热息痛(800mg/kg)建立动物急性肝损伤模型,动物处死后取血液和脏器测定各项指标。相对于模型对照组,太明清实验组的肝指数明显降低。三个剂量的太明清均明显降低血清谷丙转氨酶(ALT),谷草转氨酶(AST),碱性磷酸酶(ALP),甘油三酯(TG),尿素氮(BUN)水平,提高血清总胆固醇(TC),白蛋白(ALB)水平(p0.05)。且三个剂量呈现了一定的量效关系。其中太明清高剂量组对小鼠肝损伤的保护效果最佳,仅次于阳性药物水飞蓟素组(p0.05)。另外,从小鼠肝脏病理图来看,相对于模型对照组,太明清实验组对炎症及肝细胞坏死有明显改善。可见太明清对扑热息痛所致小鼠肝损伤具有较好的保护作用。
[Abstract]:In this study, the protective effects of Taimingqing (TMC), a traditional Korean drink, on hepatic injury induced by paracetamol in mice were studied. The mice were given low (100 mg/kg), moderate (250 mg/kg) and high (500 mg/kg) doses of Taimingqing and positive drug silymarin (100 mg/kg) for 14 days. Acute liver injury model was established by intraperitoneal injection of paracetamol (800mg/kg). Compared with the model control group, the liver index of the experimental group in Taiming and Qing dynasties decreased significantly. The levels of serum alanine aminotransferase (alt), aspartate aminotransferase (AST), alkaline phosphatase (ALP), triglyceride (TG), urea nitrogen (bun) were significantly decreased and serum total cholesterol (TC) and albumin (ALB) were increased (p0.05). The three dosages showed a dose-effect relationship. The protective effect of Taiming Qing high dose group on liver injury in mice was the best, second only to silymarin group (p0.05). In addition, compared with the model control group, the experimental group of Tai-Ming and Qing Dynasty significantly improved inflammation and hepatocyte necrosis. It can be seen that Taiming Qing has a good protective effect on paracetamol induced liver injury in mice.
【作者单位】：韩国釜山大学;重庆第二师范学院生物与化学工程系;
【基金】：重庆高校创新团队建设计划资助项目(KJTD201325)
【分类号】：R151

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