不同类型n-3 PUFA对大鼠脂联素及血脂血糖的影响

发布时间：2018-07-08 11:42

本文选题：n-多不饱和脂肪酸 + 脂联素　；参考：《营养学报》2017年01期

【摘要】：目的研究不同类型n-3多不饱和脂肪酸对大鼠脂联素及血脂、血糖水平的影响。方法 40只雄性Wistar大鼠按体质量随机分成正常脂肪供能比(27%)NF1和NF2,高脂肪供能比(42%)HF1和HF2,共4组。NF1和HF1组饲料添加二十碳五烯酸(EPA)和二十二碳六烯酸(DHA),NF2和HF2组饲料添加α-亚麻酸(ALA),喂养12 w。12 w测定肾周脂肪脂联素m RNA,测定0和12 w血清脂联素,0、4、8和12 w检测血脂和血糖。结果 0 w大鼠各指标无组间差异。12 w,NF1组肾周脂肪脂联素m RNA明显高于NF2(P0.05)。NF1和NF2两组大鼠血清脂联素、高密度脂蛋白胆固醇(HDL-C)较0 w均明显升高(P0.05),低密度脂蛋白胆固醇(LDL-C)均明显降低(P0.05),NF1较NF2组作用更显著(P0.05)。NF1组总胆固醇(TC)较0w显著下降(P0.05)。HF1和HF2两组大鼠脂联素m RNA明显低于NF1组(P0.01),血清脂联素和HDL-C也明显降低(P0.05),空腹血清血糖、LDL-C、TC和甘油三酯(TG)显著升高(P0.05)。结论相对于ALA,正常脂肪供能比时EPA+DHA更能促进大鼠肾周脂肪脂联素m RNA表达,提高血清脂联素和HDL-C含量,降低LDL-C和TC含量。高脂条件下两者作用无差异。
[Abstract]:Objective to study the effects of different types of n-3 polyunsaturated fatty acids on adiponectin, blood lipids and blood glucose levels in rats. Methods Forty male Wistar rats were randomly divided into normal fat energy supply ratio (27%) NF1 and NF2, high fat energy supply ratio (42%) HF1 and HF2 according to body weight. Four groups were fed with eicosapentaenoic acid (EPA) and 22 carbohexaenoic acid (DHA) NF2 and HF2 diet. 伪 -linolenic acid (Ala) was added to determine the perirenal adiponectin mRNA at 12 w and serum adiponectin 0 4 and blood glucose at 8 and 12 weeks after feeding. Results the serum adiponectin mRNA was significantly higher in NF-1 group than in NF2 (P0.05) .NF1 and NF2 groups. High density lipoprotein cholesterol (HDL-C) was significantly higher than 0 w (P0.05), low density lipoprotein cholesterol (LDL-C) was significantly lower (P0.05) than NF2 group (P0.05). Total cholesterol (TC) in NF1 group was significantly lower than that in 0 w group (P0.05). HF1 and HF2 groups had significantly decreased adiponectin mRNA. Lower than NF1 group (P0.01), serum adiponectin and HDL-C also decreased significantly (P0.05), fasting serum glucose level LDL-CnTC and triglyceride (TG) significantly increased (P0.05). Conclusion compared with ALAs, EPA DHA can promote adiponectin mRNA expression, increase serum adiponectin and HDL-C levels, and decrease LDL-C and TC levels in rats. There was no difference between the two groups under high fat condition.
【作者单位】：南方医科大学公共卫生学院营养与食品卫生学系;
【基金】：国家自然科学基金(No.81273072)
【分类号】：R151

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