铁过载人群临床血液学特征及对健康影响分析
发布时间：2018-08-20 18:19
【摘要】：目的机体不同铁负荷水平可引起血液学特征的变化,对机体带来不良影响。本研究旨在分析成年人群铁过载状态下临床血液学特征的变化及对部分健康因素的影响,为深入探讨铁过载对人群健康的影响及疾病预防提供参考。方法选取2014年1月~12月某医院的体检人群,按照血清铁蛋白(serum ferritin)水平随机抽取铁状态正常者113名(男性:15~200μg/L;女性:15~150μg/L)和铁过载者124名(男性:200μg/L;女性:150μg/L),年龄为40~70岁。采集空腹静脉血,检测机体铁代谢有关的血液指标,如血红蛋白、外周血细胞数量、血清铁、转铁蛋白、肝功能相关指标及矿物质水平等。对比分析两组之间的差异。结果铁代谢相关血液学指标结果显示,铁过载组人群血红蛋白(Hb)平均水平为156.16g/L,高于铁正常组147.76g/L(P0.001);红细胞数量变化分析显示,铁过载组红细胞计数达5.01×1012/L,明显高于铁正常组的4.83×1012/L(P0.05);其红细胞压积、平均红细胞体积、平均红细胞血红蛋白含量等也均显著高于铁正常组(P均0.05)。铁过载组人群血清铁为22.93μmol/L,显著高于铁正常组17.83μmol/L(P0.05);铁过载组人群转铁蛋白饱和度达到36%,显著高于铁正常组的28%(P0.05);不饱和铁结合力和转铁蛋白浓度均显著低于铁正常组(P0.05);两组间总铁结合力无统计学差异(P0.05)。血清蛋白水平分析显示,铁过载组总蛋白浓度为76.02g/L,高于铁正常组的73.64g/L(P0.05);白蛋白浓度为44.83g/L,显著高于铁正常组的43.55g/L(P0.05)。血清矿物质水平分析显示,铁过载组血清钙平均水平为2.42mmol/L,显著高于铁正常组的2.39mmol/L(P0.05);血清硒水平为51.23μg/L,显著高于铁正常组的37.21μg/L(P0.05);而血清钠、钾、镁、铬、镍、镉、锰、铜、锌离子浓度两组间均未见明显差异(P均0.05)。体格检查结果分析显示,铁过载组体质指数(BMI)为26.31kg/m2,显著高于铁正常组25.47 kg/m2(P0.05),收缩压和舒张压均显著高于铁正常组(P0.05)。肝功能相关酶类分析显示,谷丙转氨酶含量为32U/L,显著高于铁正常组的22U/L(P0.05);谷草转氨酶含量为22U/L,显著高于铁正常组的20U/L(P0.05);谷氨酰转肽酶含量38U/L,显著高于铁正常组的19U/L(P0.05)。结论铁在机体内过量沉积,可导致与铁代谢相关指标显著变化,血红蛋白、红细胞数量、体积及血清中铁含量显著增加;初步分析发现铁过载人群在BMI偏高的人群(BMI25kg/m2)中多见,肝功能相关酶的活性显著增高;然而,机体内铁过量沉积引起的机体血液学指标明显变化,是否对机体健康带来潜在危害有待深入研究。
[Abstract]:Objective different levels of iron load can cause hematological changes and bring adverse effects on the body. The purpose of this study was to analyze the changes of clinical hematological characteristics and the effects on some health factors in adult population under the condition of iron overload, and to provide a reference for further study on the effect of iron overload on population health and disease prevention. Methods from January to December 2014, 113 subjects with normal iron status (male: 1515g / L; female: 1515g / L; female: 150 渭 g / L) and 124 iron overload (male: 200 渭 g / L; female: 150 渭 g / L) were randomly selected according to the serum ferritin (serum ferritin) level, aged 4070 years. Fasting venous blood was collected to detect the blood indexes related to iron metabolism, such as hemoglobin, the number of peripheral blood cells, serum iron, transferrin, liver function and mineral level. The differences between the two groups were compared and analyzed. Results the hemoglobin (Hb) average level of iron overload group was 156.16 g / L, which was higher than that of iron normal group 147.76g/L (P0.001). The erythrocyte count in iron overload group was 5.01 脳 10 12 / L, which was significantly higher than that in iron normal group (4.83 脳 10 12 / L, P0.05), and the hematocrit, mean erythrocyte volume and mean erythrocyte hemoglobin content in iron overload group were significantly higher than those in iron normal group (P 0.05). The serum iron content of iron overload group was 22.93 渭 mol / L, which was significantly higher than that of iron normal group (17.83 渭 mol/L), the transferrin saturation of iron overload group was 36%, significantly higher than 28% of iron normal group (P0.05), the unsaturated iron binding ability and transferrin concentration were significantly lower than that of iron normal group (P0.05). There was no statistical difference in total iron binding ability between the two groups (P0.05). Serum protein level analysis showed that the total protein concentration of iron overload group was 76.02 g / L, higher than that of iron normal group 73.64g/L (P0.05), albumin concentration was 44.83 g / L, significantly higher than iron normal group 43.55g/L (P0.05). The serum mineral level in iron overload group was 2.42 mmol / L, which was significantly higher than that in iron normal group (P0.05); the serum selenium level was 51.23 渭 g / L, which was significantly higher than that in iron normal group (37.21 渭 g / L, P0.05); and the serum sodium, potassium, magnesium, chromium, nickel, cadmium, manganese, copper, sodium, potassium, magnesium, chromium, nickel, cadmium, manganese and copper in serum were significantly higher than those in normal iron group (P0.05). There was no significant difference in zinc ion concentration between the two groups (P 0.05). The results of physical examination showed that the body mass index (BMI) of iron overload group was 26.31 kg / m ~ (2), which was significantly higher than that of iron normal group (25.47 kg/m2) (P0.05), and systolic and diastolic blood pressure (DBP) were significantly higher than that of iron normal group (P0.05). Liver function related enzymes analysis showed that the content of glutamate-pyruvic transaminase (32U / L) was significantly higher than that of iron normal group (22U/L) (P0.05); the content of alanine aminotransferase (22U / L) was significantly higher than that of iron normal group (20U/L) (P0.05); the content of glutamyl transpeptidase (38UL) was significantly higher than that of iron normal group (P0.05). Conclusion excessive deposition of iron in the body can result in significant changes in the related indexes of iron metabolism, such as hemoglobin, erythrocyte number, volume and iron content in serum, and the primary analysis shows that iron overload group is more common in the population with higher BMI (BMI25kg/m2). The activity of liver function-related enzymes was significantly increased, however, the changes of hematological parameters caused by excessive iron deposition in the body, whether the potential harm to the health of the body need to be further studied.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R151
本文编号：2194564
[Abstract]:Objective different levels of iron load can cause hematological changes and bring adverse effects on the body. The purpose of this study was to analyze the changes of clinical hematological characteristics and the effects on some health factors in adult population under the condition of iron overload, and to provide a reference for further study on the effect of iron overload on population health and disease prevention. Methods from January to December 2014, 113 subjects with normal iron status (male: 1515g / L; female: 1515g / L; female: 150 渭 g / L) and 124 iron overload (male: 200 渭 g / L; female: 150 渭 g / L) were randomly selected according to the serum ferritin (serum ferritin) level, aged 4070 years. Fasting venous blood was collected to detect the blood indexes related to iron metabolism, such as hemoglobin, the number of peripheral blood cells, serum iron, transferrin, liver function and mineral level. The differences between the two groups were compared and analyzed. Results the hemoglobin (Hb) average level of iron overload group was 156.16 g / L, which was higher than that of iron normal group 147.76g/L (P0.001). The erythrocyte count in iron overload group was 5.01 脳 10 12 / L, which was significantly higher than that in iron normal group (4.83 脳 10 12 / L, P0.05), and the hematocrit, mean erythrocyte volume and mean erythrocyte hemoglobin content in iron overload group were significantly higher than those in iron normal group (P 0.05). The serum iron content of iron overload group was 22.93 渭 mol / L, which was significantly higher than that of iron normal group (17.83 渭 mol/L), the transferrin saturation of iron overload group was 36%, significantly higher than 28% of iron normal group (P0.05), the unsaturated iron binding ability and transferrin concentration were significantly lower than that of iron normal group (P0.05). There was no statistical difference in total iron binding ability between the two groups (P0.05). Serum protein level analysis showed that the total protein concentration of iron overload group was 76.02 g / L, higher than that of iron normal group 73.64g/L (P0.05), albumin concentration was 44.83 g / L, significantly higher than iron normal group 43.55g/L (P0.05). The serum mineral level in iron overload group was 2.42 mmol / L, which was significantly higher than that in iron normal group (P0.05); the serum selenium level was 51.23 渭 g / L, which was significantly higher than that in iron normal group (37.21 渭 g / L, P0.05); and the serum sodium, potassium, magnesium, chromium, nickel, cadmium, manganese, copper, sodium, potassium, magnesium, chromium, nickel, cadmium, manganese and copper in serum were significantly higher than those in normal iron group (P0.05). There was no significant difference in zinc ion concentration between the two groups (P 0.05). The results of physical examination showed that the body mass index (BMI) of iron overload group was 26.31 kg / m ~ (2), which was significantly higher than that of iron normal group (25.47 kg/m2) (P0.05), and systolic and diastolic blood pressure (DBP) were significantly higher than that of iron normal group (P0.05). Liver function related enzymes analysis showed that the content of glutamate-pyruvic transaminase (32U / L) was significantly higher than that of iron normal group (22U/L) (P0.05); the content of alanine aminotransferase (22U / L) was significantly higher than that of iron normal group (20U/L) (P0.05); the content of glutamyl transpeptidase (38UL) was significantly higher than that of iron normal group (P0.05). Conclusion excessive deposition of iron in the body can result in significant changes in the related indexes of iron metabolism, such as hemoglobin, erythrocyte number, volume and iron content in serum, and the primary analysis shows that iron overload group is more common in the population with higher BMI (BMI25kg/m2). The activity of liver function-related enzymes was significantly increased, however, the changes of hematological parameters caused by excessive iron deposition in the body, whether the potential harm to the health of the body need to be further studied.
【学位授予单位】：青岛大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R151
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