停供碘盐地区儿童妇女甲状腺容积和功能及碘营养状况分析
发布时间：2018-08-25 08:53
【摘要】：目的 了解停供碘盐后水源性高碘地区儿童和妇女的碘营养状况及当地人群甲状腺容积和功能检测情况,探讨高碘地区划定的水碘界值问题,为国家制定或调整水源性高碘地区防制策略提供科学依据。 方法 采用分层随机抽样方法,根据水碘含量将被调查村分为50μg/L～(A组)、100μg/L～(B组)、150gg/L～(C组)、300μg/L～(D组)4组。每组随机选择200名8-10岁学龄儿童和60名妇女(包括孕妇、哺乳妇女、育龄妇女各20名)作为研究对象。采集各研究对象家庭饮用水、食用盐、和随机一次尿样,分别检测水碘、盐碘、尿碘含量。检测8-10岁儿童甲状腺容积。采集妇女血样,检测甲状腺功能(FT3、FT4、TSH、Anti-TPO和Anti-Tg)。采用Excel和SPSS13.0进行数据处理和统计分析。 结果 ①A组儿章尿碘中位数为274.3μg/L,碘营养水平为高于适宜量；B、C、D组儿童的尿碘中位数均大于300μg/L,碘营养水平为碘过量。儿童尿碘水平随水碘值的升高而升高(H=403.66,v=3,P0.01)。 ②A、B组妇女尿碘中位数均在200～300μg/L之间,碘营养水平为高于适宜量。C、D组妇女,尿碘中位数均大于300μg/L,碘营养水平为碘过量。各阶段妇女尿碘中位数均随水碘值的升高而升高(χ2=100.27,v=3,P0.01)。 ③4组调查点儿童甲肿率分别为5.9%、13.0%、14.O%、11.4%,甲肿率随着水碘水平的升高而增高。 ④A、C、D三组内,孕妇FT3、FT4水平均低于哺乳妇女、育龄妇女；且随着各组调查点水碘水平的逐步升高,妇女的FT4激素水平逐渐下降,TSH水平逐渐上升。 结论 ①停供碘盐后,水碘大于100μg/L时,随着水碘含量的升高,人群的碘营养水平由超过适宜量逐渐转为碘过量,儿童甲肿率也在增大。 ②各阶段妇女在不同水碘水平下,停供碘热后其碘营养水平均能满足怀孕和哺乳需求。 ③建议将高碘地区划定标准的水碘含量切点值由150μg/L下调至100iμg/L ④在高碘地区应针对不同水碘含量,因地制宜采取不同的干预措施,综合防制高碘危害。
[Abstract]:Objective to investigate the iodine nutrition status of children and women and the thyroid volume and function of the local population in the water-source high iodine area after the discontinuation of iodized salt, and to discuss the water iodine boundary value in the high iodine area. It provides the scientific basis for the country to formulate or adjust the control strategy of water source high iodine area. Methods by stratified random sampling, the village was divided into 4 groups: group A (50 渭 g / L ~ (A) 100 渭 g / L ~ (B) and group C (300 渭 g / L ~ (C) with 300 渭 g / L ~ (D). Two hundred children aged 8 to 10 years and 60 women (including 20 pregnant women, 20 nursing women and 20 women of childbearing age) were randomly selected for each group. The contents of iodine, salt and iodine in water, salt and urine were measured. Thyroid volume was measured in children aged 8-10 years. Blood samples were collected and thyroid function (FT3,FT4,TSH,Anti-TPO and Anti-Tg) was measured. Excel and SPSS13.0 were used for data processing and statistical analysis. Results the median of urine iodine in group 1A was 274.3 渭 g / L, and the level of iodine nutrition was higher than that in group D. The median of urinary iodine in group A was more than 300 渭 g / L, and the level of iodine nutrition was iodine excess. The urinary iodine level of children increased with the increase of water iodine value (P 0.01). 2 the median of urinary iodine in group B was between 200 渭 g / L and 300 渭 g / L, and the nutritional level of iodine was higher than that in group C. the median of urinary iodine was more than 300 渭 g / L, and the nutritional level of iodine was iodine excess. The urinary iodine median of women in all stages increased with the increase of water iodine value (蠂 2100.27). The goiter rate of children in the 34 groups was 5.90.13.0 and 13.0 respectively. The goiter rate increased with the increase of water iodine level, and the rate of goiter increased with the increase of iodine level in water (P < 0.01), and the rate of goiter increased with the increase of iodine level in water (P < 0.01), and the rate of goiter increased with the increase of iodine level in water (P < 0.01). The levels of FT3,FT4 in pregnant women were lower than those in lactating women and women of childbearing age, and with the increase of iodine level in water of each group, the levels of FT4 hormones gradually decreased. Conclusion (1) when iodine in water is more than 100 渭 g / L after discontinuation of iodized salt, with the increase of iodine content in water, the iodine nutrition level of the population gradually changes from excess to excessive iodine. The rate of goiter in children is also increasing. 2 at different levels of iodine in water, The iodine nutrition level of iodine fever can meet the needs of pregnancy and lactation. 3 it is suggested that the cut point value of iodine content in water should be lowered from 150 渭 g / L to 100 I 渭 g / L 4 in high iodine area. Different intervention measures should be taken according to local conditions to prevent and control the harm of high iodine.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R172
本文编号：2202382
[Abstract]:Objective to investigate the iodine nutrition status of children and women and the thyroid volume and function of the local population in the water-source high iodine area after the discontinuation of iodized salt, and to discuss the water iodine boundary value in the high iodine area. It provides the scientific basis for the country to formulate or adjust the control strategy of water source high iodine area. Methods by stratified random sampling, the village was divided into 4 groups: group A (50 渭 g / L ~ (A) 100 渭 g / L ~ (B) and group C (300 渭 g / L ~ (C) with 300 渭 g / L ~ (D). Two hundred children aged 8 to 10 years and 60 women (including 20 pregnant women, 20 nursing women and 20 women of childbearing age) were randomly selected for each group. The contents of iodine, salt and iodine in water, salt and urine were measured. Thyroid volume was measured in children aged 8-10 years. Blood samples were collected and thyroid function (FT3,FT4,TSH,Anti-TPO and Anti-Tg) was measured. Excel and SPSS13.0 were used for data processing and statistical analysis. Results the median of urine iodine in group 1A was 274.3 渭 g / L, and the level of iodine nutrition was higher than that in group D. The median of urinary iodine in group A was more than 300 渭 g / L, and the level of iodine nutrition was iodine excess. The urinary iodine level of children increased with the increase of water iodine value (P 0.01). 2 the median of urinary iodine in group B was between 200 渭 g / L and 300 渭 g / L, and the nutritional level of iodine was higher than that in group C. the median of urinary iodine was more than 300 渭 g / L, and the nutritional level of iodine was iodine excess. The urinary iodine median of women in all stages increased with the increase of water iodine value (蠂 2100.27). The goiter rate of children in the 34 groups was 5.90.13.0 and 13.0 respectively. The goiter rate increased with the increase of water iodine level, and the rate of goiter increased with the increase of iodine level in water (P < 0.01), and the rate of goiter increased with the increase of iodine level in water (P < 0.01), and the rate of goiter increased with the increase of iodine level in water (P < 0.01). The levels of FT3,FT4 in pregnant women were lower than those in lactating women and women of childbearing age, and with the increase of iodine level in water of each group, the levels of FT4 hormones gradually decreased. Conclusion (1) when iodine in water is more than 100 渭 g / L after discontinuation of iodized salt, with the increase of iodine content in water, the iodine nutrition level of the population gradually changes from excess to excessive iodine. The rate of goiter in children is also increasing. 2 at different levels of iodine in water, The iodine nutrition level of iodine fever can meet the needs of pregnancy and lactation. 3 it is suggested that the cut point value of iodine content in water should be lowered from 150 渭 g / L to 100 I 渭 g / L 4 in high iodine area. Different intervention measures should be taken according to local conditions to prevent and control the harm of high iodine.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R172
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