油茶对高脂饮食引起大鼠肝损伤的保护作用

发布时间：2018-08-28 18:50

【摘要】：本文主要研究了油茶对高脂饮食引起的大鼠肝损伤的保护作用。试验中将大鼠分为空白对照组、高脂模型组、油茶低、中和高剂量组,每组10只。经造模期15 d和给样期32 d后,腹主动脉采血,取肝脏。测定大鼠肝脏重量,观察肝脏组织病理;分别测定血清中ALT和AST活力,血清和肝匀浆中SOD、GSH-Px活力和MDA水平。结果表明,与高脂模型组相比,油茶组肝脏系数显著降低(p0.05);血清中ALT和AST活力显著降低(p0.05);血清和肝脏中SOD和GSH-Px活力显著升高,MDA含量显著降低(p0.05);肝脏组织病理显示,油茶组能够减轻肝细胞脂肪变性。由结果可知:油茶能够缓解高脂饮食大鼠肝脏肥大,增强机体抗脂质过氧化能力,缓解肝脏脂肪变性,对肝脏损伤起到有效的保护作用,其中油茶高剂量组作用最明显。
[Abstract]:The protective effect of Camellia oleifera on liver injury induced by high fat diet in rats was studied. Rats were divided into blank control group, high fat model group, low, medium and high dose Camellia oleifera groups with 10 rats in each group. The blood was collected from the abdominal aorta and the liver was taken from the abdominal aorta after 15 days of model making and 32 days of sample feeding. The activity of ALT and AST in serum, the activity of SOD,GSH-Px and MDA in serum and liver homogenate were measured. The results showed that compared with the high-fat model group, the liver coefficient of Camellia oleifera group was significantly lower (p0.05), the activity of ALT and AST in serum decreased significantly (p0.05), the activity of SOD and GSH-Px in serum and liver increased significantly (p0.05). Camellia oleifera group can reduce fatty degeneration of hepatocytes. The results showed that Camellia oleifera could relieve liver hypertrophy, enhance the ability of anti-lipid peroxidation, alleviate hepatic steatosis and protect liver injury, especially in the high dose group of Camellia oleifera.
【作者单位】：广西大学轻工与食品工程学院;广西大学食品质量与安全研究中心;
【基金】：广西高校特色农产品精深加工与安全控制重点实验室资助广西“食品生物技术”岗位八桂学者团队资助
【分类号】：R151.41

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