HBsAg阳性母亲所生新生儿乙肝疫苗和HBIG联合免疫后的抗体持久性观察

发布时间：2018-09-07 17:31

【摘要】：目的观察乙肝表面抗原(HBsAg)阳性孕妇所生新生儿采取重组酵母乙型肝炎疫苗(10μg,0-1-6三针)联合乙肝免疫球蛋白(HBIG,100IU或200IU)免疫后3年内的抗体持久性,为制定科学强化免疫策略提供依据。方法新生儿7月龄时及1岁、2岁和3岁时分别采血,追踪观察按照免疫程序免疫后3年内儿童的抗-HBs动态变化情况及持久性。结果儿童的抗-HBs无应答、低应答、正常应答和高应答率分别由7个月时的0.76%、5.34%、38.17%、53.18%(有2.54%感染HBV),变为3岁时的25.13%、44.67%、18.73%和7.68%(有3.79%感染HBV),差异有统计学意义(P0.001)。3岁时低应答和累计无应答率达到69.80%。抗-HBs几何平均滴度由7个月时的997.56mIU/ml降为3岁时的59.06mIU/ml。7个月时为低应答、正常应答和高应答的,各有一例在3岁前感染。结论母亲HBsAg阳性的,需定期检测抗-HBs,免疫后1-2年加强免疫。
[Abstract]:Objective to observe the antibody-persistence of recombinant yeast hepatitis B vaccine (10 渭 g 0-1-6) combined with hepatitis B immunoglobulin (HBIG,100IU) or hepatitis B immunoglobulin (200IU) in newborns born with hepatitis B surface antigen (HBsAg) positive pregnant women within 3 years, so as to provide scientific evidence for the formulation of enhanced immunization strategy. Methods Blood samples were collected at 7 months old, 1 year old and 2 years old and 3 years old respectively. The dynamic changes and persistence of anti-HBs in children within 3 years after immunization were observed. Results the rates of anti-HBs non-response, low response, normal response and high response were 38.175.34% (2.54%) and 25.13% (18.73%) and 7.68% (3.79%) respectively. The geometric mean titer of anti-HBs decreased from 7 months old to 3 years old 59.06mIU/ml.7 at 3 months of low response, normal response and high response, one case of infection before 3 years old. Conclusion in mothers with HBsAg positive, anti-HBs should be detected regularly, and immunization should be strengthened in 1-2 years after immunization.
【作者单位】：郑州市疾病预防控制中心;北京大学医学部;新密市妇幼保健院;巩义市妇幼保健院;中牟县妇幼保健院;郑州市妇幼保健院;郑州市金水区总医院;
【基金】：国家科技重大专项资助(2008ZX10002-001,2012ZX10002-001)
【分类号】：R186

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