高功率微波辐射对家兔心肌形态和心肌酶影响

发布时间：2018-09-18 10:50

【摘要】：目的探讨高功率微波(HPM)辐射对家兔心肌形态结构和心肌酶的影响。方法新西兰家兔24只,雌雄各半,随机分为对照组和微波辐射高、中、低密度组,辐射功率分别为200、150、100 m W/cm2,每组6只,辐射20 min,辐射后6 h,股动脉取血,检测心肌酶活性,冰浴下立即取心肌心尖部组织,制作常规光镜标本并观察。结果微波辐射后6 h时,与对照组比较,微波辐射低密度组家兔血清肌酸激酶同工酶、肌酸激酶和乳酸脱氢酶活性[分别为(619.5±268.3)、(841.7±131.4)和(376.5±149.6)U/L]明显升高,差异有统计学意义(P0.05),呈剂量效应关系;光镜下大部分心肌细胞胞浆疏松淡染,部分心肌纤维断裂,心肌间质内血管扩张充血、伴有炎性细胞浸润,病变程度与辐射功率呈正相关。结论高功率微波辐射对家兔心肌具有损伤作用,损伤效应包括心肌结构与心肌酶改变。
[Abstract]:Objective to investigate the effects of high power microwave (HPM) radiation on myocardial morphology and myocardial enzymes in rabbits. Methods Twenty-four New Zealand rabbits, half male and half female, were randomly divided into two groups: the control group and the high, medium and low density groups. The radiation power was 200150100 MW / cm ~ (2). Six rabbits in each group were irradiated for 20 min,. The femoral artery blood was taken and the myocardial enzyme activity was measured. The myocardial apical tissue was taken immediately under ice bath, and the normal light microscope specimen was made and observed. Results at 6 h after microwave irradiation, serum creatine kinase isoenzyme, creatine kinase and lactate dehydrogenase activity [(619.5 卤268.3), (841.7 卤131.4) and (376.5 卤149.6) U / L] were significantly increased in low density rabbits compared with control group. The difference was statistically significant (P0.05), showing a dose-effect relationship. Under the light microscope, the majority of myocardial cells were loose and light stained, some of the myocardial fibers were broken, and the interstitial blood vessels were dilated and congested with inflammatory cell infiltration. The degree of lesion was positively correlated with radiation power. Conclusion High power microwave irradiation can damage the myocardium of rabbits, including the changes of myocardial structure and myocardial enzymes.
【作者单位】：吉林医药学院病理教研室;吉林医药学院生化教研室;吉林医药学院机能教研室;吉林医药学院;吉林医药学院吉林省微波重点实验室;
【基金】：吉林省教育厅项目(吉教科合字2010第251号;吉教科合字2012第495号;吉教科合字2013第348号)
【分类号】：R14

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