降钙素受体基因与氟性骨损伤相关因素的交互作用

发布时间：2018-10-05 11:26

【摘要】：[目的]分析与评价职业性氟接触人群降钙素受体基因(CTR)多态性及其与氟性骨损伤相关因素的交互作用,为氟性骨损伤干预政策及措施的制定提供理论依据。[方法]对湖北省某铝厂氟暴露工人245例进行流行病学调查和实验室检查,以右前臂和骨盆X射线正位片确定的氟性骨损伤119例作为病例组,其余126例作为对照组。检测病例组和对照组工人的CTR基因多态性、血氟(BF)、尿氟(UF)、血清骨钙素(BGP)、降钙素(CT)、碱性磷酸酶(ALP)和骨特异性碱性磷酸酶(BALP)等指标。[结果]氟暴露工人CTR基因型为CC型169例(69.0%),TC型70例(28.6%),TT型6例(2.4%);C、T等位基因频率分别为83.3%和16.7%。影响氟性骨损伤发生的独立危险因素为饮酒,UF高、BGP高、CT高、BALP高及CTR基因型(非CC型),其OR值分别为1.729,1.217,1.579,1.049,1.024和14.620。CTR T等位基因与UF存在正相加模型交互作用[交互作用超额相对危险度(RERI)=14.34(95%CI:1.47~32.16),交互作用归因比(API)=0.75(95%CI:0.50~1.00),交互作用指数(S)=4.7(95%CI:1.65~14.89)]。[结论]本次研究的结果显示饮酒,UF、BGP、CT、BALP高和CTR基因型(非CC型)是氟性骨损伤的危险因素,CTR T等位基因与UF在氟性骨损伤的发生中存在交互作用。
[Abstract]:[objective] to analyze and evaluate the (CTR) polymorphism of calcitonin receptor gene and its interaction with the factors related to fluorine bone injury in occupational fluorine-exposed population, and to provide a theoretical basis for the formulation of intervention policies and measures for fluorine bone injury. [methods] A total of 245 workers exposed to fluorine in an aluminum factory in Hubei Province were investigated in epidemiology and laboratory. 119 cases of fluorine bone injury confirmed by X-ray positive radiographs of right forearm and pelvis were taken as the case group and the remaining 126 cases as the control group. The polymorphisms of CTR gene, serum osteocalcin (BGP), calcitonin (CT), alkaline phosphatase (ALP) and bone specific alkaline phosphatase (BALP) in serum fluorine (BF), urine fluorine (UF), were detected. [results] the allele frequencies of CTR genotype in fluorine exposed workers were 83.3% (169 / 169), CC (69.0%), TC (28.6%) and TT (2.4%), respectively. The independent risk factors for fluorine bone injury were high BALP and high CTR genotype (non-CC), OR values were 1.7291.2171. 579 1. 049 and 14.620.CTR T alleles had positive additive model interaction with UF. The frontal relative risk (RERI) was 14.34 (95%CI:1.47~32.16), the interaction attribution ratio was (API) 0.75 (95%CI:0.50~1.00), and the interaction index (95%CI:1.65~14.89) was (S) 4. 7 (95%CI:1.65~14.89). [conclusion] the results of this study indicate that the high level of CTBALP and the CTR genotype (non-CC type) are the risk factors of fluorine bone injury. CTRT allele and UF may play an important role in the occurrence of fluorine bone injury.
【作者单位】：成都市疾病预防控制中心职业病防制科;华中科技大学同济医学院公共卫生学院劳动卫生与环境卫生学系;
【基金】：国家自然科学基金项目(编号:81372941)
【分类号】：R135

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