产妇高龄对新生儿出生缺陷及生后并发症的影响

发布时间：2018-11-20 10:58

【摘要】：目的探讨产妇高龄对新生儿出生缺陷及生后并发症的影响。方法 2014年1月至2015年12月在云南省第一人民医院入住的1 109例新生儿中,选取年龄≥35岁的高龄产妇所产新生儿536例作为高龄组,随机选取同期分娩的年龄35岁的适龄产妇所产新生儿573例作为适龄组。比较两组产妇妊娠期合并症、胎儿宫内窘迫及新生儿出生缺陷、生后并发症等情况;通过单因素logistic回归分析产妇高龄对新生儿围产期合并症的影响。结果高龄组产妇剖宫产率、多胎次、妊娠期糖尿病、妊高症、试管婴儿、胎儿宫内窘迫发生率均显著高于适龄组,差异均有统计学意义(P0.01);高龄组新生儿唇腭裂发生率高于适龄组,骨骼畸形率低于适龄组(P0.05)。高龄是造成胎儿宫内窘迫(OR=2.27;95%CI:1.33~3.88;P=0.003)、新生儿复苏(OR=1.66;95%CI:1.19~2.31;P=0.003)和颅内出血(OR=2.70;95%CI:1.21~6.04;P=0.02)的危险因素。结论高龄产妇妊娠期合并症发生率高于适龄产妇,其所产新生儿唇腭裂发生率高于适龄产妇;产妇高龄会增加胎儿宫内窘迫、新生儿复苏抢救和颅内出血的风险。
[Abstract]:Objective to investigate the effect of old age on neonatal birth defects and postnatal complications. Methods from January 2014 to December 2015, 536 newborns were enrolled in the first people's Hospital of Yunnan Province, and 536 newborns who were older than 35 years old were selected as the old age group. A total of 573 newborns born at 35 years of age were randomly selected as the right age group. The complications of pregnancy, fetal distress, birth defects and complications were compared between the two groups, and the influence of old women on perinatal complications was analyzed by univariate logistic regression analysis. Results the rate of cesarean section, multiple births, gestational diabetes mellitus, PIH, IVF and fetal distress in the elderly group were significantly higher than those in the right age group (P0.01). The incidence of cleft lip and palate was higher and the rate of bone deformity was lower in the old age group than that in the right age group (P0.05). Advanced age is associated with fetal distress (OR=2.27;95%CI:1.33~3.88;P=0.003), neonatal resuscitation (OR=1.66;95%CI:1.19~2.31;P=0.003) and intracranial hemorrhage (OR=2.70;95%CI:1.21~6.04;). P0. 02). Conclusion the incidence of complications in gestational period is higher than that in the age group, and the incidence of cleft lip and palate in the newborn is higher than that in the age group, and the risk of fetal distress, resuscitation of newborn and intracranial hemorrhage is increased at old age.
【作者单位】：大理大学临床医学院儿科;云南省第一人民医院/昆明理工大学附属昆华医院儿科;
【基金】：云南省应用研究项目资助(2011WS0004)
【分类号】：R174

【相似文献】