宫内或环境中的邻苯二甲酸酯对6岁儿童的性激素水平及生殖发育的影响

发布时间：2019-02-20 08:43

【摘要】：邻苯二甲酸酯的抗雄激素作用可能影响暴露儿童的生殖发育。因此我们研究了宫内或环境暴露邻苯二甲酸酯的6岁儿童的生殖发育情况。我们招募了120位川东北地区2010年出生的儿童,并跟踪调查至2016年直至这些儿童年满6周岁。我们收集整理了每位儿童的出生结局,测定其骨龄、激素水平及邻苯二甲酸酯的代谢产物(邻苯二甲酸单酯(MEHP),邻苯二甲酸单丁酯(Mn BP))的水平,并评估了这些儿童的生殖发育情况。母亲尿液中邻苯二甲酸酯类代谢产物的水平与6岁儿童出生时的情况、生理特征及生殖激素的水平并不明显相关。而6岁儿童尿液中邻苯二甲酸酯类代谢产物MEHP与血清中黄体酮的水平显著相关,尤其是女孩尿液中MEHP的水平。所有儿童Mn BP的水平与血清FSH的水平显著相关。尿液邻苯二甲酸酯类代谢产物的水平与6岁儿童的生长及生殖器官的发育并不相关。因此,环境暴露邻苯二甲酸酯可能会影响儿童生殖激素的水平。邻苯二甲酸酯的环境健康效应还有待进一步研究。
[Abstract]:Anti-androgen effects of phthalates may affect reproductive development in exposed children. So we studied the reproductive development of 6-year-old children exposed to phthalate in uterus or environment. We recruited 120 children born in 2010 in Northeast Sichuan and tracked them until 2016 until they reached the age of 6. We collected and sorted out the birth outcomes of each child, measured their bone age, hormone levels and metabolites of phthalates (MEHP), monobutyl phthalate (Mn BP). The reproductive development of these children was evaluated. The level of phthalate metabolites in maternal urine was not significantly correlated with the state of birth, physiological characteristics and reproductive hormone levels of children aged 6 years. However, MEHP, a metabolite of phthalate in urine, was significantly correlated with the level of progesterone in serum, especially the level of MEHP in the urine of girls. The level of Mn BP in all children was significantly correlated with the level of serum FSH. The level of phthalate metabolites in urine is not related to the growth and reproductive organ development of 6-year-old children. Environmental exposure to phthalates may therefore affect reproductive hormone levels in children. The environmental health effects of phthalates need further study.
【作者单位】：川北医学院附属医院小儿外科;川北医学院附属医院检验科;
【基金】：川北医学院附属医院资助
【分类号】：R114

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