米非司酮与米索前列醇合用在早期药物流产中的效果探究
发布时间：2019-02-22 19:31
【摘要】：目的观察并探讨米非司酮与米索前列醇合用早期药物流产中的临床疗效。方法选择自2013年8月至2014年12月在三门县中医院进行早期(8~12周)药物流产的患者96例,按照随机数字法将96例患者分为两组,每组各48例,对照组单纯口服米非司酮治疗,观察组在对照组基础上联合米索前列醇口服治疗。统计两组流产成功率和不良反应情况,并记录两组胚囊排出时间、清宫2h出血量和阴道流血时间。结果观察组流产成功率为91.7%,对照组流产成功率为75.0%,两组相比,差异具有统计学意义(P0.05);观察组胚囊排出时间、清宫2 h出血量和阴道流血时间分别为(265.5±104.4)min、(32.4±9.2)ml和(8.2±0.8)d,对照组为(259.7±112.7)min、(38.7±12.4)ml和(13.5±1.4)d,两组比较,差异有统计学意义(P0.05);观察组不良反应率为8.3%(4/48),对照组为6.3%(3/48),两组相比,差异无统计学意义(P0.05)。结论米非司酮与米索前列醇联合使用在早期药物流产中,流产成功率高,清宫后出血量和流血时间更短,且不明显增加不良反应,是安全有效的早期药流方案。
[Abstract]:Objective to observe the clinical effect of mifepristone combined with misoprostol on early abortion. Methods Ninety-six patients with early (812 weeks) drug abortion were selected from August 2013 to December 2014 in Sanmen County traditional Chinese Medicine Hospital. 96 patients were randomly divided into two groups, 48 cases in each group. The control group was treated with mifepristone only. Observation group on the basis of the control group combined with misoprostol oral treatment. The success rate and adverse reaction of abortion in the two groups were counted, and the time of embryo sac excretion, 2 hours of uterine bleeding and vaginal bleeding were recorded. Results the success rate of abortion was 91.7 in the observation group and 75.0 in the control group. The difference between the two groups was statistically significant (P0.05). The efflux time of embryo sac, 2 h blood loss and vaginal bleeding time were (265.5 卤104.4) min, (32.4 卤9.2) ml and (8.2 卤0.8) d in the observation group and (259.7 卤112.7) min, in the control group, respectively. (38.7 卤12.4) ml and (13.5 卤1.4) d, the difference was statistically significant (P0.05). The adverse reaction rate was 8.3% (4 / 48) in the observation group and 6.3% (3 / 48) in the control group. There was no significant difference between the two groups (P0.05). Conclusion Mifepristone combined with misoprostol is a safe and effective regimen for early drug abortion.
【作者单位】： 浙江大学医学院附属第一医院三门湾分院三门县中医院;
【分类号】：R169.42
，
本文编号：2428540
[Abstract]:Objective to observe the clinical effect of mifepristone combined with misoprostol on early abortion. Methods Ninety-six patients with early (812 weeks) drug abortion were selected from August 2013 to December 2014 in Sanmen County traditional Chinese Medicine Hospital. 96 patients were randomly divided into two groups, 48 cases in each group. The control group was treated with mifepristone only. Observation group on the basis of the control group combined with misoprostol oral treatment. The success rate and adverse reaction of abortion in the two groups were counted, and the time of embryo sac excretion, 2 hours of uterine bleeding and vaginal bleeding were recorded. Results the success rate of abortion was 91.7 in the observation group and 75.0 in the control group. The difference between the two groups was statistically significant (P0.05). The efflux time of embryo sac, 2 h blood loss and vaginal bleeding time were (265.5 卤104.4) min, (32.4 卤9.2) ml and (8.2 卤0.8) d in the observation group and (259.7 卤112.7) min, in the control group, respectively. (38.7 卤12.4) ml and (13.5 卤1.4) d, the difference was statistically significant (P0.05). The adverse reaction rate was 8.3% (4 / 48) in the observation group and 6.3% (3 / 48) in the control group. There was no significant difference between the two groups (P0.05). Conclusion Mifepristone combined with misoprostol is a safe and effective regimen for early drug abortion.
【作者单位】： 浙江大学医学院附属第一医院三门湾分院三门县中医院;
【分类号】：R169.42
，
本文编号：2428540
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