焦炉工尿中多环芳烃羟基代谢产物影响因素分析

发布时间：2019-05-30 02:46

【摘要】：目的观察焦炉工尿中4种多环芳烃(PAHs)羟基代谢产物水平及其影响因素,探讨其作为焦炉逸散物(COEs)接触的生物标志物的可行性。方法采用横断面调查方法,以某焦化厂261名焦炉工为接触组,以某氧气厂111名非焦炉作业工人为对照组。采用超高液相色谱-质谱法检测2组人群尿中1-羟基芘、1-羟基萘、2-羟基萘和3-羟基菲4种PAHs羟基代谢产物的水平。结果接触组人群尿中4种PAHs羟基代谢产物水平均高于对照组(P0.01);接触组3个亚组人群尿中1-羟基芘、1-羟基萘和2-羟基萘水平从低到高依次为炉底亚组炉侧亚组炉顶亚组(P0.05)。多重逐步回归分析结果显示:在排除性别、年龄、吸烟和饮酒等混杂因素的影响后,尿中1-羟基芘、1-羟基萘和2-羟基萘水平均与接触COEs有关联(P0.05);在排除性别、年龄、工龄、吸烟和饮酒等混杂因素的影响后,接触组人群尿中1-羟基芘、1-羟基萘和2-羟基萘水平均呈随COEs接触水平增加而增加的剂量-效应关系(P0.01);接触组人群尿中1-羟基萘和2-羟基萘水平还与吸烟有关联(P0.01)。结论 1-羟基芘可作为COEs内暴露评价的可靠生物标志物,1-羟基萘和2-羟基萘可作为COEs内暴露评价的辅助生物标志物。
[Abstract]:Objective to observe the level of (PAHs) hydroxyl metabolites of four polycyclic aromatic hydrocarbons (PAHs) in coke oven workers' urine and its influencing factors, and to explore the feasibility of PAHs as biomarkers of coke oven escape (COEs) exposure. Methods 261 coke oven workers in a coking plant were used as the contact group and 111 non-coke oven workers as the control group by means of cross-section investigation. The levels of PAHs hydroxyl metabolites in urine of two groups were determined by ultra-high liquid chromatography-mass spectrometry (HPLC-MS). The results showed that 1-hydroxypyrene, 1-hydroxynaphthalene, 2-hydroxynaphthalene and 3-hydroxyphenanthrene were used to determine the levels of hydroxyl metabolites in urine of two groups. Results the levels of four kinds of PAHs hydroxyl metabolites in urine of the exposed group were higher than those of the control group (P 0.01). The levels of 1-hydroxypyrene, 1-hydroxyNaphthalene and 2-hydroxyNaphthalene in urine of the three subgroups in the exposure group were in turn the furnace top subgroup of the furnace side subgroup from low to high (P 0.05). The results of multiple stepwise regression analysis showed that 1-hydroxypyrene, 1-hydroxynaphthalene and 2-hydroxyNaphthalene in urine were associated with exposure to COEs on average after excluding the effects of sex, age, smoking and drinking (P 0.05). After excluding the effects of sex, age, length of service, smoking and drinking, 1-hydroxypyrene was found in the urine of the exposed group. 1-hydroxynaphthalene and 2-hydroxynaphthalene water showed an average dose-effect relationship with the increase of COEs exposure level (P01). The levels of 1-hydroxyNaphthalene and 2-hydroxyNaphthalene in urine of the exposed group were also associated with smoking (P 0.01). Conclusion 1-hydroxypyrene can be used as a reliable biomarker for COEs exposure evaluation, and 1-hydroxynaphthalene and 2-hydroxynaphthalene can be used as auxiliary biomarkers for COEs exposure evaluation.
【作者单位】：山东省职业卫生与职业病防治研究院;中国疾病预防控制中心职业卫生与中毒控制所;济南市疾病预防控制中心;
【基金】：国家科技支撑计划项目(2014BAI12B02) 国家自然科学基金(81172642)
【分类号】：R135

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