银川市大气污染对出生缺陷影响的病例交叉研究

发布时间：2019-06-11 22:34

【摘要】：目的了解银川市2013—2014年大气污染物浓度与人群暴露水平,定量分析和评价该市大气污染物与出生缺陷的暴露-反应关系及其关键窗口期。方法收集银川市2013年10月1日—2014年12月31日出生缺陷个案资料,以及该市2013年1月1日—2014年12月31日空气质量数据、气象资料。采用病例交叉设计分析大气污染物浓度与出生缺陷的暴露-反应关系。结果研究期间银川市大气PM2.5年均浓度为51μg/m~3,PM10年均浓度为114μg/m~3,SO_2年平均浓度为73μg/m~3,NO_2年平均浓度为43μg/m~3,均高于GB 3095—2012《环境空气质量标准》国家二级标准限值。在控制气象因素的影响下,妊娠后前3个月大气PM2.5、PM10、SO_2浓度每升高10μg/m~3,可能会增加出生缺陷的发生风险,OR(95%CI)分别为1.017(1.013~1.022),1.011(1.009~1.014),1.002(1.001~1.003);分娩前第1个月NO_2、CO浓度每升高10μg/m~3可能会增加出生缺陷的风险,OR(95%CI)分别为1.003(1.001~1.006),1.106(1.018~1.202);分娩前第2个月NO_2每升高10μg/m~3可能会增加出生缺陷的风险,OR(95%CI)为1.008(1.005~1.011);分娩前3个月大气PM2.5、PM10、NO_2、CO浓度每升高10μg/m~3可能会增加出生缺陷的风险,OR(95%CI)分别为1.008(1.005~1.011),1.013(1.010~1.015),1.012(1.009~1.015),1.208(1.106~1.320),均有统计学意义(P0.05)。结论银川市大气污染较重,妊娠早期是PM2.5、PM10、SO_2对出生缺陷影响的关键窗口期,妊娠晚期是NO_2、CO对出生缺陷影响的关键窗口期。
[Abstract]:Objective to investigate the concentration of air pollutants and population exposure level in Yinchuan City from 2013 to 2014, and to quantitatively analyze and evaluate the exposure-response relationship between air pollutants and birth defects in Yinchuan City and its key window period. Methods the data of birth defects in Yinchuan City from October 1, 2013 to December 31, 2014, as well as the air quality data and meteorological data from January 1, 2013 to December 31, 2014 were collected. The relationship between air pollutant concentration and exposure-response to birth defects was analyzed by case cross design. Results during the study period, the average annual concentration of atmospheric PM2.5 was 51 渭 g / m, the average annual concentration of PM10 was 114 渭 g / m, the average concentration of so _ 2 was 73 渭 g / m, and the average concentration of no _ 2 was 43 渭 g / m, which was higher than the national standard limit of GB 3095 / 2012. Under the influence of meteorological factors, for every 10 渭 g / m 鈮，

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