微波辐射对家兔血清心肌酶活性及心脏血流动力学的影响

发布时间：2018-01-01 02:27

本文关键词：微波辐射对家兔血清心肌酶活性及心脏血流动力学的影响　出处：《辐射防护》2016年06期 　论文类型：期刊论文

【摘要】：采用平均功率密度为100 m W/cm2和200 m W/cm2的微波照射新西兰家兔20 min,探讨微波辐射对家兔心肌酶活性及心脏血流动力学影响及其意义。结果表明,微波照射5 min后,家兔呼吸(R)、心率(HR)加快。100 m W/cm2照射10~15 min后,家兔血压(BP)和左心室收缩压(LVSP)升高,左心室内压最大上升速率(+dp/dtm)和左心室内压最大下降速率(-dp/dtm)增加,左心室舒张压(LVDP)和左心室终末舒张压(LVEDP)下降,等容舒张时间室内压下降的时间常数(T)值减小;心电图(ECG)R波、QR波异常,偶发全身抽搐。200 m W/cm2照射5 min后,ECG异常以R波、QR波畸形较多,有锯齿形波,出现多次全身抽搐;照射15~20 min时,LVDP明显下降,T值减小,+dp/dtm和-dp/dtm明显增加。照射停止后,各组家兔R、HR立刻减慢,BP下降。停止照射6 h时,R、HR继续减慢,BP不断下降,LVSP逐渐降低,+dp/dtm和-dp/dtm减少,LVDP和LVEDP逐渐升高,T值增大。照射后各组家兔血清心肌酶活性明显升高。实验证明高功率微波辐射对家兔心脏结构和舒缩功能有明显影响,且损伤作用与照射强度密切相关。
[Abstract]:Using microwave irradiation the average power density of 100 m W/cm2 and 200 m W/cm2 20 min New Zealand rabbits, to investigate the effect and significance of myocardial enzymes and cardiac hemodynamics under microwave irradiation. The results showed that microwave irradiation 5 min, heart rate, respiration in rabbits (R) (HR) and.100 m W/cm2 10~15 min soon after irradiation rabbits, blood pressure (BP) and left ventricular systolic pressure (LVSP) increased, left ventricular pressure maximal rate of rise (+dp/dtm) and left ventricular pressure decline rate (-dp/dtm) increased, left ventricular diastolic pressure (LVDP) and left ventricular end diastolic pressure (LVEDP) decreased, isovolumic relaxation time of ventricular pressure decreased the time constant (T) decreased; electrocardiogram (ECG) R wave, QR wave abnormalities, occasional convulsions.200 m W/cm2 5 min after irradiation, ECG abnormal R wave, QR wave abnormalities more, with a serrated wave, repeated convulsions; 15~20 radiation min, LVDP decreased significantly, T value reduced +dp/dtm And -dp/dtm increased significantly. After cessation of irradiation, the rabbits were R, HR immediately slowed down, BP decreased. Irradiation 6 h, R, HR continues to slow down, BP decreased gradually, LVSP decreased gradually, +dp/dtm and -dp/dtm decreased, LVDP and LVEDP increased gradually, T value increased. Blood group rabbit myocardial enzymes activity increased significantly after irradiation. The experiment results show that the high power microwave radiation on rabbit cardiac structure and diastolic function has obvious effect, and the damage effect and the radiation intensity are closely related.

【作者单位】：吉林医药学院;
【基金】：国家自然科学基金资助项目(No:81301450) 吉林省卫生厅科技计划项目(No:2012Z066)
【分类号】：R818
【正文快照】： 随着科学技术的高速发展,微波已广泛应用于通讯、医疗、交通、军事等相关领域,随之而来的环境辐射污染日趋严重,造成的辐射损伤已成为影响人类健康的重要物理因素之一。微波辐射对机体造成的生物效应早已引起人们的高度关注[1-3],心脏作为微波辐射较为敏感的靶器官之一,辐射对

【参考文献】