绝经后妇女椎体脆性骨折的双能X线骨密度仪评估及其与血清骨转化、骨代谢指标的关系

发布时间：2018-01-13 15:29

本文关键词：绝经后妇女椎体脆性骨折的双能X线骨密度仪评估及其与血清骨转化、骨代谢指标的关系　出处：《海南医学院学报》2016年21期 　论文类型：期刊论文

【摘要】：目的:研究绝经后妇女椎体脆性骨折双能X线骨密度测量结果与血清骨转化、骨代谢指标的关系。方法:选择2012年4月~2015年12月期间在复旦大学附属上海市第五人民医院接受DXA检查的158例绝经后妇女,根据骨密度测量结果分为骨质疏松组、骨量减少组、骨质正常组,根据胸腰椎正侧位片结果分为无椎体骨折组、胸椎骨折组、腰椎骨折组、胸腰椎骨折组,采集血清并测定骨转化和骨代谢指标。结果:胸椎骨折、胸腰椎骨折受试者的股骨颈、髋部、腰椎L1~4骨密度显著低于无椎体骨折的受试者,腰椎骨折受试者的股骨颈、髋部、腰椎L1~4骨密度与无椎体骨折的受试者无显著性差异;骨质疏松组、骨量减少组绝经后妇女血清中PINP、ICTP、CTX、TRACP-5b、MMP13、OPG、OPN含量显著高于骨量正常组,25(OH)D、BGP、ON含量显著低于骨量正常组;骨质疏松组绝经后妇女血清中PINP、ICTP、CTX、TRACP-5b、MMP13、OPG、OPN含量显著高于骨量减少组,25(OH)D、BGP、ON含量显著低于骨量减少组。结论:双能X线骨密度测定对绝经后妇女胸椎脆性骨折和胸腰椎脆性骨折的预测价值明确且与骨转化、骨代谢的改变密切相关。
[Abstract]:Objective: To study the postmenopausal women with vertebral fracture dual energy bone density measurements and X-ray conversion relationship between serum bone, bone metabolism index. Methods: April 2012 ~2015 year in December at the Fudan University affiliated Fifth People's Hospital of Shanghai, received DXA examination of 158 cases of postmenopausal women, according to the measurement of bone mineral density results were divided into osteoporosis group osteopenia group, normal group, osteoporosis, according to thoracic and lumbar radiographs were divided into non vertebral fracture group, thoracic fracture group, lumbar fracture group, thoracolumbar fracture group, serum and determination of bone turnover and bone metabolism index. Results: thoracic vertebral fracture, the subjects of the femoral neck, thoracic and lumbar fractures hip bone density in L1~4 was significantly lower than that of the subjects without vertebral fracture, lumbar fracture subjects of femoral neck, hip, there was no significant difference in bone density in L1~4 and non vertebral fracture subjects; osteoporosis group, bone mass reduction Small group of postmenopausal women in serum PINP, ICTP, CTX, TRACP-5b, MMP13, OPG, OPN were significantly higher than that in normal bone mass group, 25 (OH) D, BGP, ON were significantly lower than normal bone mass group; osteoporosis group of postmenopausal women in serum PINP, ICTP, CTX, TRACP-5b, MMP13, OPG, OPN the content was significantly higher than that of osteopenia group, 25 (OH) D, BGP, ON were significantly lower in osteopenia group. Conclusion: dual energy X-ray bone density determination of predictive value of postmenopausal women with thoracic and thoracolumbar fracture of brittle fracture of brittle bone and clear and transformation, is closely related to bone metabolism changes.

【作者单位】：复旦大学附属上海市第五人民医院核医学科;
【基金】：上海市第五人民医院科研课题(2013WYQJ05)~~
【分类号】：R580;R683;R816.8
【正文快照】： group and osteopenia group were significantly higher than those of normal bone mass group while 25(OH)D,BGP and ON con-tent were significantly lower than those of normal bone mass group;serum PINP,ICTP,CTX,TRACP-5b,MMP13,OPGand OPN content of osteoporosi

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